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Stereospecific synthesis of chiral metabolites of ifosfamide and their determination in the urine.
The measurements performed in the presence of optically active lanthanide shift reagent showed considerable stereoselectivity of in vivo formation of some chiral metabolites of ifosfamide. Expand
Antimalarial activities of oligodeoxynucleotide phosphorothioates in chloroquine-resistant Plasmodium falciparum.
It is reported that oligodeoxynucleotide phosphorothioates and their nuclease-resistant modifications are effective in micromolar and submicromolar concentrations against the growth of both chloroquine-resistant and chloroquin-sensitive strains of Plasmodium falciparum in vitro. Expand
Analysis of the urinary excretion of ifosfamide and its N-dechloroethylated metabolites in children using 31P-NMR spectroscopy.
Amounts of ifosfamide (CAS 3778-73-2) and its N-dechloroethylated metabolites excreted in the urine were measured using 31P-NMR spectroscopy in 26 cancer children treated with this drug. StrongExpand
Anti-sense oligodeoxynucleoside phosphorothioates nonspecifically inhibit invasion of red blood cells by malaria parasites.
Both anti-sense and sense oligodeoxynucleoside phosphorothioates inhibit invasion of red blood cells by merozoites and this is interpreted as being caused by their polyanionic nature. Expand
Synthesis, antimicrobial evaluation and theoretical prediction of NMR chemical shifts of thiazole and selenazole derivatives with high antifungal activity against Candida spp.
Abstract Synthesis and investigation of antimicrobial activities of novel thiazoles and selenazoles is presented. Their structures were determined using NMR, FAB(+)-MS, HRMS and elemental analyses.Expand
[Classical oxazaphosphorines--metabolism and therapeutic properties--new implications].
Since CPA and IFO are widely used anticancer drugs, their efficacy is limited not only by their toxicity but also due to occurring resistance, which seems to be a result of changes of expression and activity of enzymes such as CYP and aldehyde dehydrogenase and increase of intracellular levels of glutathione. Expand
Deoxyxylothymidine 3′-O-phosphorothioates: Synthesis, stereochemistry and stereocontrolled incorporation into oligothymidylates
Abstract New reagent, 5′-O-DMT-xylothymidine 3′-O-(2-thio-4,4-spiropentamethylene-1,3,2-oxathiaphospholane) and its separated diastereomers can be used for stereocontrolled incorporation ofExpand
Synthesis and antitumor activity of analogues of ifosfamide modified in the N-(2-chloroethyl) group.
Only bromo analogue 13 and its enantiomers were effective, exceeding the activity of racemic ifosfamide and cyclophosphamide, and the therapeutic index of the racemic 12 and its levorotatory enantiomer was about 1.7 times higher than that for ifosFamide. Expand
(S)-(−)-Bromofosfamide (CBM-11): synthesis and antitumor activity and toxicity in mice
(S)-(−)-Bromofosfamide (CBM-11), an enantiomerically pure bromo analog of ifosfamide, was found to be potent against several model tumors in mice. Therapeutic indices of CBM-11 were more favorable asExpand