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Protection by a radical scavenger edaravone against cisplatin-induced nephrotoxicity in rats.
Acute renal failure is a dose-limiting factor of cisplatin chemotherapy. Here, we show the protective effect of edaravone, a recently developed radical scavenger for clinical use, againstExpand
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Involvement of Substance P in Peripheral Neuropathy Induced by Paclitaxel but Not Oxaliplatin
The painful peripheral neuropathy occurring frequently during chemotherapy with paclitaxel or oxaliplatin is one of their dose-limiting factors. We reported previously that substance P is involved inExpand
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Inhibitory effects of calcitonin gene-related peptide on substance-P-induced superoxide production in human neutrophils.
We examined the mechanisms of the inhibitory effects of calcitonin gene-related peptide (CGRP) on substance-P-induced superoxide anion (O2-) production in human neutrophils. Substance P (30 microM)Expand
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Roles of protein kinase C and Ca2+-dependent signaling in angiotensin II-induced adrenomedullin production in rat cardiac myocytes
Objectives We showed that angiotensin II stimulates adrenomedullin production in cultured neonatal rat cardiac myocytes, and that the secreted adrenomedullin inhibits hypertrophy of the myocytes,Expand
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Molecular mechanisms for alpha2-adrenoceptor-mediated regulation of synoviocyte populations.
The sympathetic nervous system has been indicated to influence the severity of inflammatory disease including rheumatoid arthritis. In this study, we elucidated the effects of catecholamine on theExpand
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Phorbol 12-myristate 13-acetate (PMA)-induced oxyradical production in rheumatoid synovial cells.
We successfully detected the oxyradical production in human synovial A (macrophage-like) and B (fibroblast-like) cells by phorbol 12-myristate 13-acetate (PMA) using the luminol-chemiluminescenceExpand
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Original Contribution Protective effect of cyclic AMP against cisplatin-induced nephrotoxicity
We reported earlier that reactive oxygen species are implicated in necrotic injury induced by a transient exposure of cultured renal tubular cells to a high concentration of cisplatin but not inExpand
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Involvement of anion exchange in the hypoxia/reoxygenation-induced changes in pH(i) and.
The involvement of Cl(-)/HCO(3)(-) exchange in hypoxia/reoxygenation-induced changes in pH(i) and Ca(2+) concentration ([Ca(2+)](i)) was examined in rat ventricular myocytes. During 10-min hypoxia,Expand
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Prediction method for decreases in blood pressure during hemocatharsis therapy by arteriolar blood flow measurement
In clinical practice, the prediction of changes in blood pressure during hemocatharsis therapy depends on invasive monitoring, the physician's experience, or blood pressure measurement when patientsExpand
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Roles of Pharmacist as a Member of the Liver Transplant team in Controlling Tacrolimus whole Blood Concentrations and Monitoring Adverse Drug Events such as Convulsion.
This study aimed to evaluate the role of the pharmacist as a member of the liver transplant team in controlling tacrolimus concentrations and the incidence of convulsions as a sideExpand
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