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Cannabidiol Prevents Cerebral Infarction Via a Serotonergic 5-Hydroxytryptamine1A Receptor–Dependent Mechanism
The results suggested that the neuroprotective effect of cannabidiol may be related to the increase in CBF through the serotonergic 5-HT1A receptor.
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice.
- T. Kaifu, J. Nakahara, T. Takai
- Medicine, BiologyThe Journal of clinical investigation
- 1 February 2003
The results provide a molecular basis for a unique combination of skeletal and psychotic characteristics of Nasu-Hakola disease as well as for schizophrenia and presenile dementia.
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau
- Y. Tatebayashi, T. Miyasaka, A. Takashima
- BiologyProceedings of the National Academy of Sciences…
- 4 October 2002
These mice that exhibit a phenotype mimicking R406W FTDP-17 provide an animal model for investigating the adverse properties associated with this mutation, which might potentially recapitulate some etiological events in Alzheimer's disease.
Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder.
Magnetic resonance imaging shows delayed ischemic striatal neurodegeneration
The hyperintensity on T1‐weighted MRI after mild ischemia may involve tissue Mn accumulation accompanied by Mn‐SOD and GS induction in reactive astrocytes, which correspond to striatal neurodegeneration with a chronic inflammatory response and signs of oxidative stress, and subjects with these MRI changes are at risk for showing a late impairment of brain function even though the transient ischemía is followed by total neurological recovery.
Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor‐independent myeloperoxidase‐inhibiting mechanism
Cannabidiol provides potent and long‐lasting neuroprotection through an anti‐inflammatory CB1 receptor‐independent mechanism, suggesting that cannabidio will have a palliative action and open new therapeutic possibilities for treating cerebrovascular disorders.
Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice
Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats.
The results suggest that in this repeated cerebral ischemia model, the 4-oxo group and the 2,3-double bond in the C ring of rutin and quercetin are related to their neuroprotective action.
Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism