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Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound
Canonical transient receptor potential (TRPC) channels control influxes of Ca2+ and other cations that induce diverse cellular processes upon stimulation of plasma membrane receptors coupled toExpand
TRIC channels are essential for Ca2+ handling in intracellular stores
Cell signalling requires efficient Ca2+ mobilization from intracellular stores through Ca2+ release channels, as well as predicted counter-movement of ions across the sarcoplasmic/endoplasmicExpand
Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF‐κB regulation
LUBAC (linear ubiquitin chain assembly complex) activates the canonical NF‐κB pathway through linear polyubiquitination of NEMO (NF‐κB essential modulator, also known as IKKγ) and RIP1. However, theExpand
Three-dimensional Reconstruction Using Transmission Electron Microscopy Reveals a Swollen, Bell-shaped Structure of Transient Receptor Potential Melastatin Type 2 Cation Channel*
Transient receptor potential melastatin type 2 (TRPM2) is a redox-sensitive, calcium-permeable cation channel activated by various signals, such as adenosine diphosphate ribose (ADPR) acting on theExpand
The baseplate wedges of bacteriophage T4 spontaneously assemble into hubless baseplate-like structure in vitro.
The baseplate of phage T4 is an important model system in viral supramolecular assembly. The baseplate consists of six wedges surrounding the central hub. We report the first successful attempt atExpand
Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
Keap1 is a substrate adaptor of a Cullin 3-based E3 ubiquitin ligase complex that recognizes Nrf2, and also acts as a cellular sensor for xenobiotics and oxidative stresses. Nrf2 is a transcriptionalExpand
Low Cholesterol Triggers Membrane Microdomain-dependent CD44 Shedding and Suppresses Tumor Cell Migration*
CD44 is a cell surface adhesion molecule for hyaluronan and is implicated in tumor invasion and metastasis. Proteolytic cleavage of CD44 plays a critical role in the migration of tumor cells and isExpand
Inhibitors of the hyaluronidases.
  • K. Mio, R. Stern
  • Chemistry, Medicine
  • Matrix biology : journal of the International…
  • 2002
The inhibitors of hyaluronidase present in mammalian sera, first described half a century ago, have remained uncharacterized. Because of increased interest in hyaluronidases and their hyaluronanExpand
Visualization of the trimeric P2X2 receptor with a crown-capped extracellular domain.
The P2X2 purinergic receptor permeates cationic ions in response to stimulation by ATP and mediates fast synaptic transmission. Here, we purified the P2X2 receptor using baculovirus-Sf9 cellExpand
The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas.
Transient receptor potential (TRP) channels are intrinsic sensors adapted for response to all manner of stimuli both from inside and from outside the cell. Within the TRP superfamily, the canonicalExpand
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