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Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs
The Cul4–Rbx1–DDB1–Cereblon E3 ubiquitin ligase complex is the target of thalidomide, lenalidomide and pomalidomide, therapeutically important drugs for multiple myeloma and other B-cellExpand
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Development of Marine Toxicity Data for Ordnance Compounds
A toxicity database for ordnance compounds was generated using eight compounds of concern and marine toxicity tests with five species from different phyla. Toxicity tests and endpoints includedExpand
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Gelatinase B and TIMP‐1 are regulated in a cell‐ and time‐dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia
Matrix metalloproteinases (MMPs) belong to a large family of endopeptidases that regulate the pericellular environment through the cleavage of protein components of the extracellular matrix, membraneExpand
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Processing of tumour necrosis factor-α precursor by metalloproteinases
TUMOUR necrosis factor-α (TNF-α) is a potent pro-inflammatory and immunomodulatory cytokine implicated in inflammatory conditions such as rheumatoid arthritis, Crohn's disease, multiple sclerosis andExpand
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Transferrin receptors promote the formation of clathrin lattices
Gold conjugates have been used to quantitate human transferrin receptors (hTfnRs) on transfected chick embryo fibroblasts. No relationship could be found between the number of hTfnRs and the numberExpand
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Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells
We have followed the internalization pathway of both epidermal growth factor (EGF) and its receptor in human epidermoid carcinoma (A431) cells. Using EGF conjugated with horseradish peroxidase andExpand
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Receptor-Mediated Endocytosis of Transferrin and Epidermal Growth Factor Receptors: A Comparison of Constitutive and Ligand-Induced Uptake
SUMMARY The distribution of cell surface receptors for transferrin–iron and epidermal growth factor (EGF) on the surface of cultured epitheloid (A431) cells has been identified by immunocytochemicalExpand
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Localisation of the protein and glycoprotein components of bovine nasal epithelial desmosomes by immunoelectron microscopy.
Desmosomal proteins (dp1‐4) and glycoproteins (dg1‐3) have been localised within desmosomes of bovine nasal epithelium by immunogold labelling of ultrathin frozen sections. Beginning in theExpand
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Monoclonal antibodies against defined epitopes of the human transferrin receptor cytoplasmic tail.
Three murine monoclonal antibodies (mAbs) against the 61-residue amino-terminal cytoplasmic tail of the human transferrin receptor (TR) have been produced by immunization of mice with recombinantExpand
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Sediment Toxicity Identification Evaluation (TIE) Studies at Marine Sites Suspected of Ordnance Contamination
A sediment quality assessment survey and subsequent toxicity identification evaluation (TIE) study was conducted at several sites in Puget Sound, Washington. The sites were previously suspected ofExpand
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