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INCIDENCE AND SEVERITY OF ANAPHYLACTOID REACTIONS TO COLLOID VOLUME SUBSTITUTES
TLDR
All available colloid volume substitutes carry the risk of anaphylactoid reactions, but the frequency of severe reactions was low for plasma-protein solutions, hydroxyethyl starch, 0-008% for dextran, and 0-038% for gelatin solutions. Expand
Orthogonal polarization spectral imaging: A new method for study of the microcirculation
TLDR
Orthogonal polarization spectral (OPS) imaging is reported here on, a new method for imaging the microcirculation using reflected light that allows imaging of the micro Circulation noninvasively through mucus membranes and on the surface of solid organs. Expand
Platelet-endothelial cell interactions during ischemia/reperfusion : The role of P-selectin
TLDR
First in vivo evidence is provided that platelets accumulate in the postischemic microvasculature early after reperfusion via P-selectin-ligand interactions, indicating that platelet recruitment and subsequent activation might play an important role in the pathogenesis of I/R injury. Expand
Platelet-endothelial cell interactions during ischemia/reperfusion: the role of P-selectin.
TLDR
First in vivo evidence is provided that platelets accumulate in the postischemic microvasculature early after reperfusion via P-selectin-ligand interactions, indicating that platelet recruitment and subsequent activation might play an important role in the pathogenesis of I/R injury. Expand
Pancreatic ischaemia in experimental acute pancreatitis: Mechanism, significance and therapy
TLDR
Isovolaemic haemodilution in conjunction with conventional fluid therapy may provide a new and effective means of protecting the pancreas from secondary injury due to the early ischaemic phase of acute pancreatitis. Expand
Noninvasive Measurement of Regional Cerebral Blood Flow by Near-Infrared Spectroscopy and Indocyanine Green
TLDR
Data presented demonstrate that detection of tracer kinetics in the cerebrovasculature by NIRS may serve as valuable tool for the noninvasive estimation of regional CBF. Expand
Small‐volume resuscitation: from experimental evidence to clinical routine. Advantages and disadvantages of hypertonic solutions
TLDR
A small‐volume resuscitatioin using hypertonic solutions encompasses the rapid infusion of a small dose of 7.2–7.5% NaCl/colloid solution for initial therapy of severe hypovolemia and shock associated with trauma. Expand
Liver ischemia and reperfusion induces a systemic inflammatory response through Kupffer cell activation.
TLDR
The data indicate that hepatic ischemia/reperfusion results in Kupffer cell activation and increased cytokine levels, which may produce systemic inflammation and may be responsible for tissue injury locally and on remote sites. Expand
Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.
TLDR
This is the first model enabling intravital microscopic studies of human tumor xenografts in a transparent chamber preparation in severe combined immunodeficient mice, and should provide new insights into microcirculation-mediated mechanisms for cancer treatment. Expand
Fibrinogen deposition at the postischemic vessel wall promotes platelet adhesion during ischemia-reperfusion in vivo.
Following ischemia-reperfusion (I/R), platelet adhesion is thought to represent the initial event leading to remodeling and reocclusion of the vasculature. The mechanisms underlying platelet adhesionExpand
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