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Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype
Postmortem AD brains exhibit dendritic spine loss in the hippocampus. To determine whether this pathology may be associated with amyloid burden, the present study used the Golgi stain technique toExpand
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Serotonin 2C receptors within the basolateral amygdala induce acute fear-like responses in an open-field environment
Several studies indicate a role for the serotonin 2 subfamily (5-HT(2A), 5-HT(2B), 5-HT(2C)) in mediation of fear and anxiety responses. The current study began to examine the effects of stimulatingExpand
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Studies of Aβ Pharmacodynamics in the Brain, Cerebrospinal Fluid, and Plasma in Young (Plaque-Free) Tg2576 Mice Using the γ-Secretase Inhibitor
A previous study by us suggests the utility of cerebrospinal fluid (CSF) and plasma Aβ as biomarkers of β- or γ-secretase inhibition. The present study characterized further Aβ pharmacodynamics inExpand
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Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat
In the rat, administration of the psychoactive analog of amphetamine 3,4-methylenedioxymethamphetamine (MDMA), causes selective, pronounced decreases in markers of central serotonergic function. TheExpand
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Distinct 5-HT1B and 5-HT1D serotonin receptors in rat: Structural and pharmacological comparison of the two cloned receptors
We and others have recently cloned the genes encoding the human 5-HT(1D) (5-HT(1Dalpha)) and 5-HT(1B) (5-HT(1Dbeta)) serotonin receptors. Because of the history of profound species differences in theExpand
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Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychotics.
  • K. Merchant, D. Dorsa
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 15 April 1993
Precise neural mechanisms underlying the pathophysiology and pharmacotherapy of psychotic disorders remain largely unknown. Present studies investigated the effects of various antipsychotic drugs onExpand
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Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist.
Dopamine D2-like receptors play an important role in the pharmacotherapy of psychotic disorders. Molecular and cellular techniques have identified distinct gene products (D2-long, D2-short, D3 andExpand
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Differential regulation of behavioral, genomic, and neuroendocrine responses by CRF infusions in rats
Studies suggest that behavioral, genomic, and endocrine functions mediated by central corticotropin-releasing factor (CRF)-containing circuits may be differentially regulated. However, thisExpand
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Positive and Negative Regulation of the γ-Secretase Activity by Nicastrin in a Murine Model*
Nicastrin is a component of the γ-secretase complex that has been shown to adhere to presenilin-1 (PS1), Notch, and APP. Here we demonstrate that Nicastrin-deficient mice showed a phenotype that isExpand
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Differential effects of haloperidol and clozapine on neurotensin gene transcription in rat neostriatum
A single dose of typical neuroleptic, haloperidol, has been demonstrated to increase the expression of neurotensin/neuromedin N (NT/N) mRNA in the dorsolateral striatum within 1 hr of itsExpand
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