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- Publications
- Influence
Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype
- T. Lanz, D. Carter, K. Merchant
- Biology, Medicine
- Neurobiology of Disease
- 1 August 2003
Postmortem AD brains exhibit dendritic spine loss in the hippocampus. To determine whether this pathology may be associated with amyloid burden, the present study used the Golgi stain technique to… Expand
Serotonin 2C receptors within the basolateral amygdala induce acute fear-like responses in an open-field environment
- B. Campbell, K. Merchant
- Psychology, Medicine
- Brain Research
- 12 December 2003
Several studies indicate a role for the serotonin 2 subfamily (5-HT(2A), 5-HT(2B), 5-HT(2C)) in mediation of fear and anxiety responses. The current study began to examine the effects of stimulating… Expand
Studies of Aβ Pharmacodynamics in the Brain, Cerebrospinal Fluid, and Plasma in Young (Plaque-Free) Tg2576 Mice Using the γ-Secretase Inhibitor…
- T. Lanz, J. D. Hosley, W. Adams, K. Merchant
- Medicine
- Journal of Pharmacology and Experimental…
- 1 April 2004
A previous study by us suggests the utility of cerebrospinal fluid (CSF) and plasma Aβ as biomarkers of β- or γ-secretase inhibition. The present study characterized further Aβ pharmacodynamics in… Expand
Immediate and long-term effects of 3,4-methylenedioxymethamphetamine on serotonin pathways in brain of rat
- D. M. Stone, K. Merchant, G. Hanson, J. Gibb
- Chemistry, Medicine
- Neuropharmacology
- 1 December 1987
In the rat, administration of the psychoactive analog of amphetamine 3,4-methylenedioxymethamphetamine (MDMA), causes selective, pronounced decreases in markers of central serotonergic function. The… Expand
Distinct 5-HT1B and 5-HT1D serotonin receptors in rat: Structural and pharmacological comparison of the two cloned receptors
- M. Hamblin, R. McGuffin, M. A. Metcalf, D. Dorsa, K. Merchant
- Biology, Medicine
- Molecular and Cellular Neuroscience
- 1 December 1992
We and others have recently cloned the genes encoding the human 5-HT(1D) (5-HT(1Dalpha)) and 5-HT(1B) (5-HT(1Dbeta)) serotonin receptors. Because of the history of profound species differences in the… Expand
Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychotics.
- K. Merchant, D. Dorsa
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 April 1993
Precise neural mechanisms underlying the pathophysiology and pharmacotherapy of psychotic disorders remain largely unknown. Present studies investigated the effects of various antipsychotic drugs on… Expand
Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist.
- K. Merchant, G. S. Gill, +13 authors R. Tenbrink
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 December 1996
Dopamine D2-like receptors play an important role in the pharmacotherapy of psychotic disorders. Molecular and cellular techniques have identified distinct gene products (D2-long, D2-short, D3 and… Expand
Differential regulation of behavioral, genomic, and neuroendocrine responses by CRF infusions in rats
- B. Campbell, J. Morrison, E. Walker, K. Merchant
- Psychology, Medicine
- Pharmacology Biochemistry and Behavior
- 1 March 2004
Studies suggest that behavioral, genomic, and endocrine functions mediated by central corticotropin-releasing factor (CRF)-containing circuits may be differentially regulated. However, this… Expand
Positive and Negative Regulation of the γ-Secretase Activity by Nicastrin in a Murine Model*
Nicastrin is a component of the γ-secretase complex that has been shown to adhere to presenilin-1 (PS1), Notch, and APP. Here we demonstrate that Nicastrin-deficient mice showed a phenotype that is… Expand
Differential effects of haloperidol and clozapine on neurotensin gene transcription in rat neostriatum
- K. Merchant, P. Dobner, D. Dorsa
- Biology, Medicine
- The Journal of neuroscience : the official…
- 1 February 1992
A single dose of typical neuroleptic, haloperidol, has been demonstrated to increase the expression of neurotensin/neuromedin N (NT/N) mRNA in the dorsolateral striatum within 1 hr of its… Expand