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Interaction between Mo(VI) and siderophore models in aqueous solution
A series of dihydroxamic acids (HORNOC-(CH2)n-CONROH, where if R=H– then n=2,5–7 and if R=CH3– then n=4,5) and two new dihydroxamate-based siderophore models, hexanedioic acid bisExpand
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A new treatment regime for sodium azide to evoke experimental Alzheimer's disease for pharmacological screening
Alzheimer's disease (AD) is characterized by a progressive decline of cognitive functions. Comparative studies identified that there are no detectable signs of drug-induced changes in cognitiveExpand
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Lipofectin‐aided cell delivery of ribozyme targeted to human urokinase receptor mRNA
A 37‐mer hammerhead ribozyme has been designed to efficiently cleave the 1.4 kb mRNA of the urokinase plasminogen activator receptor (uPAR). Under in vitro conditions, the chemically synthesizedExpand
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Loop‐F of the &agr;‐subunit determines the pharmacologic profile of novel competitive inhibitors of GABAA receptors
ABSTRACT The neurotransmitter &ggr;‐amino butyric acid (GABA) has a fundamental role in CNS function and ionotropic (GABAA) receptors that mediate many of the actions of GABA are importantExpand
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Effects of 2,3-benzodiazepine AMPA receptor antagonists on dopamine turnover in the striatum of rats with experimental parkinsonism
Although levodopa is the current "gold standard" for treatment of Parkinson's disease, there has been disputation on whether AMPA receptor antagonists can be used as adjuvant therapy to improve theExpand
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Persistent therapeutic effect of a novel &agr;5‐GABAA receptor antagonist in rodent preclinical models of vascular cognitive impairment
ABSTRACT This study examined the potential of the selective extra‐synaptic &agr;5‐GABAA receptor inhibitor S44819 (Egis‐13529) to improve cognitive performance in preclinical models of vascularExpand
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Results of a new cognitive method in rats on the Morris water maze used in modeling experimental Alzheimer's disease
Materials and methods The CA3 neurons were chemically lesioned by intracerebrally administration of NaN3 in doses of 8 and 16 mg/ml. To examine learning functions Morris maze was used. DuringExpand