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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
Distinct modifications of histone amino termini, such as acetylation, phosphorylation and methylation, have been proposed to underlie a chromatin-based regulatory mechanism that modulates the… Expand
Regulation of chromatin structure by site-specific histone H3 methyltransferases
The organization of chromatin into higher-order structures influences chromosome function and epigenetic gene regulation. Higher-order chromatin has been proposed to be nucleated by the covalent… Expand
Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability
Histone H3 lysine 9 methylation has been proposed to provide a major "switch" for the functional organization of chromosomal subdomains. Here, we show that the murine Suv39h histone… Expand
The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl
To generate different cell types, some cells can segregate protein determinants into one of their two daughter cells during mitosis. In Drosophila neuroblasts, the Par protein complex localizes… Expand
Wapl Controls the Dynamic Association of Cohesin with Chromatin
Cohesin establishes sister-chromatid cohesion from S phase until mitosis or meiosis. To allow chromosome segregation, cohesion has to be dissolved. In vertebrate cells, this process is mediated in… Expand
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.
Methylation of position-specific lysine residues in histone N termini is a central modification for regulating epigenetic transitions in chromatin. Each methylatable lysine residue can exist in a… Expand
Asymmetric Segregation of the Tumor Suppressor Brat Regulates Self-Renewal in Drosophila Neural Stem Cells
How stem cells generate both differentiating and self-renewing daughter cells is unclear. Here, we show that Drosophila larval neuroblasts-stem cell-like precursors of the adult brain-regulate… Expand
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.
Histone lysine methylation has important roles in the organization of chromatin domains and the regulation of gene expression. To analyze its function and modulate its activity, we screened for… Expand
Universal and confident phosphorylation site localization using phosphoRS.
- Thomas Taus, T. Köcher, +4 authors K. Mechtler
- Chemistry, Medicine
- Journal of proteome research
- 10 November 2011
An algorithm for the assignment of phosphorylation sites in peptides is described. The program uses tandem mass spectrometry data in conjunction with the respective peptide sequences to calculate… Expand
Sororin Mediates Sister Chromatid Cohesion by Antagonizing Wapl
Sister chromatid cohesion is essential for chromosome segregation and is mediated by cohesin bound to DNA. Cohesin-DNA interactions can be reversed by the cohesion-associated protein Wapl, whereas a… Expand