K. Mechtler | Semantic Scholar

Publications
Influence

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

M. Lachner, D. O’Carroll, S. Rea, K. Mechtler, T. Jenuwein
Biology, Chemistry
Nature
1 March 2001

It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.

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Regulation of chromatin structure by site-specific histone H3 methyltransferases

S. Rea, F. Eisenhaber, T. Jenuwein
Biology
Nature
10 August 2000

A functional interdependence of site-specific H3 tail modifications is revealed and a dynamic mechanism for the regulation of higher-order chromatin is suggested.

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Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

A. Peters, D. O’Carroll, T. Jenuwein
Biology
Cell
2 November 2001

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The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl

J. Betschinger, K. Mechtler, J. Knoblich
Biology
Nature
20 March 2003

Genetic and biochemical experiments show that Lgl phosphorylation prevents the localization of cell fate determinants to the apical cell cortex, and it is proposed thatosphorylation of Lgl by aPKC at the apICAL neuroblast cortex restricts Lgl activity and Miranda localization to the opposite, basal side of the cell.

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Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.

A. Peters, S. Kubicek, T. Jenuwein
Biology, Chemistry
Molecular cell
1 December 2003

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Wapl Controls the Dynamic Association of Cohesin with Chromatin

Stephanie Kueng, Björn Hegemann, J. Peters
Biology
Cell
1 December 2006

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Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

S. Kubicek, R. O'Sullivan, T. Jenuwein
Biology, Chemistry
Molecular cell
9 February 2007

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Asymmetric Segregation of the Tumor Suppressor Brat Regulates Self-Renewal in Drosophila Neural Stem Cells

Joerg Betschinger, K. Mechtler, J. Knoblich
Biology
Cell
24 March 2006

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Sororin Mediates Sister Chromatid Cohesion by Antagonizing Wapl

Tomoko Nishiyama, R. Ladurner, J. Peters
Biology
Cell
24 November 2010

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Universal and confident phosphorylation site localization using phosphoRS.

Thomas Taus, T. Köcher, K. Mechtler
Chemistry
Journal of proteome research
10 November 2011

An algorithm for the assignment of phosphorylation sites in peptides that includes a novel approach to peak extraction, required for matching experimental data to the theoretical values of all isoforms, by defining individual peak depths for the different regions of the tandem mass spectrum is described.

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