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Neurotoxic acylpolyamines from spider venoms
The ability of some species to produce and deliver venoms that paralyze and/or kill their prey is clearly an extremely important factor in the chemical ecology of this fascinating group of arachnids.
Pharmacological Characterization of the Novel Histamine H3-Receptor Antagonist N-(3,5-Dichlorophenyl)-N′-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687)
SCH 79687 is an orally active H3 antagonist with a good pharmacokinetic profile that, in combination with an H1 antagonist, demonstrates decongestant efficacy comparable with oral sympathomimetic decongESTants but without hypertensive liabilities.
STRUCTURE AND TOTAL SYNTHESIS OF HF-7, A NEUROACTIVE GLYCONUCLEOSIDE DISULFATE FROM THE FUNNEL-WEB SPIDER HOLOLENA CURTA
Spider venom toxins have attracted considerable attention for their ability to block the action of excitatory amino acids such as glutamate and aspartate. A new neuroactive compound designated HF-7…
Azamacrolides: a family of alkaloids from the pupal defensive secretion of a ladybird beetle (Epilachna varivestis).
- A. Attygalle, K. Mccormick, C. L. Blankespoor, T. Eisner, J. Meinwald
- ChemistryProceedings of the National Academy of Sciences…
- 1 June 1993
Defensive droplets from glandular hairs of the pupa of the Mexican bean beetle contain a group of structurally novel alkaloids, the azamacrolides, which are shown to be (5Z)-11-propyl-12-azacyclotetradec-5-en-14-olide and trace amounts of three closely related components.
Alkaloids of the Mexican bean beetle, Epilachna varivestis (Coccinellidae)
Defensive role of tropical tree resins: antitermitic sesquiterpenes from Southeast Asian Dipterocarpaceae
- A. Messer, K. Mccormick, Sunjaya, H. Hagedorn, F. Tumbel, J. Meinwald
- BiologyJournal of Chemical Ecology
- 1 December 1990
Results suggest that these sesquiterpenes, which occur in many dipterocarps, play an important role in defense against insects.
Diel Foraging Patterns of Male Euglossine Bees: Ecological Causes and Evolutionary Responses by Plants
L'activite journaliere des abeilles est comparee pour differents composes et a des sites differents pour un moment donne de la journee and en fonction des conditions meteorologiques.
Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold.
Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template.