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TRANSMUCOSAL MOVEMENT OF SELENIUM.
The transmucosal movement of selenium in the everted intestinal sacs of the golden hamsters was studied and it was found that selenomethionine was transported against a concentration gradient, and selenite andselenocystine were not.
Methionine‐selenomethionine parallels in rat liver polypeptide chain synthesis
Experimental evidence is presented which demonstrates that in rat liver as in E. coli, Se Met is incorporated into polypeptides via the Met pathway.
Serum selenium and reticuloendothelial tumors
Serum selenium levels were determined by neutron activation analysis on 59 patients with a variety of reticuloendothelial neoplasms by examining the widely variable range in the serum concentrations of the trace element with the parameters employed in this study.
S-adenosyl-L-methionine:thioether S-methyltransferase, a new enzyme in sulfur and selenium metabolism.
- N. Mozier, K. McCONNELL, J. L. Hoffman
- Medicine, ChemistryThe Journal of biological chemistry
- 5 April 1988
Data suggest a general role for this novel enzyme in the synthesis of onium compounds with increased aqueous solubility helpful in their excretion in selenium detoxification.
Periodate-oxidized adenosine inhibits the formation of dimethylselenide and trimethylselenonium ion in mice treated with selenite.
The results verify the enzymatic nature of selenium methylation in vivo, support its importance in detoxification, and indicate the value of Adox in further studies ofselenium metabolism.
Toxicity of Dimethyl Selenide in the Rat and Mouse
- K. McCONNELL, O. Portman
- Chemistry, MedicineProceedings of the Society for Experimental…
- 1 February 1952
It was found, after intraperitoneal injection of dimethyl selenide, that the median lethal dose for the mouse was 1.3 g of Se as dimethylSe per kg of body weight, and 1.6 g Se for the rat.
Relationship between serum selenium levels and patients with carcinoma
An association was noted between the serum selenium levels and patient survival time, incidence of multiple primary malignancies, rate of recurrence of the primary lesion and the extent of local and disseminated involvement.
Distribution and excretion studies in the rat after a single subtoxic subcutaneous injection of sodium selenate containing radioselenium.
- K. McCONNELL
- 1 November 1941
Studies on the fixation of radioselenium in proteins.
The relationship of dietary selenium and breast cancer
The difference noted between the mean serum Se concentrations of breast cancer patients and controls were found to be significant and the addition of Se to the diet has been shown to decrease the incidence of spontaneous murine mammary tumors.