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Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy
We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells ofExpand
Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening.
The NMR solution structure of a 13-residue metastin peptide in a membrane-like environment (SDS micelles) is reported and it is found to have a relatively stable helix conformation from residues 7 to 13 and key elements of this pharmacophore site bind to the metastin receptor and act as full agonists, albeit with reduced potency compared to that of metastin itself. Expand
Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice
Stable peptide inhibitors are designed that specifically disrupt proinflammatory CCL5-CXCL4 interactions, thereby attenuating monocyte recruitment and reducing atherosclerosis without the aforementioned side effects. Expand
Scheduling of Radiation with Angiogenesis Inhibitors Anginex and Avastin Improves Therapeutic Outcome via Vessel Normalization
The oxygen elevation in tumors by non–growth factor–mediated peptide anginex suggests that vessel normalization might be a general phenomenon of agents directed at disrupting the tumor vasculature by a variety of mechanisms. Expand
Platelet Factor 4 and Interleukin-8 CXC Chemokine Heterodimer Formation Modulates Function at the Quaternary Structural Level*
NMR spectroscopy and molecular modeling are used to provide direct evidence that tetrameric platelet factor-4 (PF4) and dimeric interleukin-8 (IL8) readily interact by exchanging subunits and forming heterodimers via extension of their antiparallel β-sheet domains. Expand
Eosinophil Peroxidase Oxidation of Thiocyanate
It is proposed that EPO/SCN−/H2O2reaction products comprise a potential SH-targeted cytotoxic system that functions in striking contrast to HOCl, the highly but relatively indiscriminantly reactive product of the neutrophil myeloperoxidase system. Expand
Platelet factor 4 promotes adhesion of hematopoietic progenitor cells and binds IL-8: novel mechanisms for modulation of hematopoiesis.
It is concluded that PF4 has the capacity to influence hematopoiesis through mechanisms not mediated by a classical high-affinity, 7-transmembrane domain chemokine receptor, and may modulate the heMatopoietic milieu both directly and indirectly by promoting progenitor adhesion and quiescence through interaction with an HPC chondroitin sulfate-containing moiety. Expand
Anti‐angiogenesis therapy can overcome endothelial cell anergy and promote leukocyte‐endothelium interactions and infiltration in tumors
The new angiostatic designer peptide anginex was most potent at overcoming EC anergy; the enhanced leukocyte‐vessel interactions led to an increase in the numbers of tumor infiltrating leukocytes, and the current results suggest that immunotherapy strategies can be improved by combination with anti‐angiogenesis. Expand
Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications.
The data show that ICAM-1 is epigenetically silenced in tumor endothelial cells by promoter histone modifications, which can be overcome by DNMT and HDAC inhibitors, suggesting a new molecular mechanism based on which novel therapeutic approaches for cancer can be pursued. Expand