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Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system
A widespread system used by bacteria for protection against potentially dangerous foreign DNA molecules consists of the clustered regularly interspaced short palindromic repeats (CRISPR) coupled withExpand
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Naturally Occurring Off-Switches for CRISPR-Cas9
CRISPR-Cas9 technology would be enhanced by the ability to inhibit Cas9 function spatially, temporally, or conditionally. Previously, we discovered small proteins encoded by bacteriophages thatExpand
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Structural proteomics of an archaeon
A set of 424 nonmembrane proteins from Methanobacterium thermoautotrophicum were cloned, expressed and purified for structural studies. Of these, ∼20% were found to be suitable candidates for X-rayExpand
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Ig-like domains on bacteriophages: a tale of promiscuity and deceit.
The immunoglobulin (Ig) fold is one of the most important structures in biology, playing essential roles in the vertebrate immune response, cell adhesion, and many other processes. ThroughExpand
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Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species
CRISPR-Cas systems provide sequence-specific adaptive immunity against foreign nucleic acids1,2. They are present in approximately half of all sequenced prokaryotes3 and are expected to constitute aExpand
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Protein folding: Defining a “standard” set of experimental conditions and a preliminary kinetic data set of two‐state proteins
Recent years have seen the publication of both empirical and theoretical relationships predicting the rates with which proteins fold. Our ability to test and refine these relationships has beenExpand
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A Broad-Spectrum Inhibitor of CRISPR-Cas9
CRISPR-Cas9 proteins function within bacterial immune systems to target and destroy invasive DNA and have been harnessed as a robust technology for genome editing. Small bacteriophage-encodedExpand
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Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex
Genetic conflict between viruses and their hosts drives evolution and genetic innovation. Prokaryotes evolved CRISPR-mediated adaptive immune systems for protection from viral infection, and virusesExpand
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Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteins
The battle for survival between bacteria and the viruses that infect them (phages) has led to the evolution of many bacterial defence systems and phage-encoded antagonists of these systems. ClusteredExpand
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Cohort profile: the PATH through life project.
Centre for Mental Health Research, Australian National University, Canberra, ACT, Australia, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia, OrygenExpand
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