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The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist.
In vitro metabolism of bimatoprost was investigated and hydrolysis product is identical to the free acid of latanoprost with the exception of a double, rather than a single, bond at the carbon 13-14 position, which may account for the reduction of intraocular pressure occurring in patients treated with bim atoprost. Expand
A quantitative solid-phase enzymeimmunoassay for 13,14-dihydro-15-keto- prostaglandin F2 alpha in plasma.
The EIA developed in this project is a valid and reliable method for quantitating PGFM in extracts of bovine plasma. Expand
The nature and composition of 15-deoxy-Delta(12,14)PGJ(2).
Purification of class I medullipins from the venous effluent of isolated normal kidneys perfused under high pressure with saline.
The results show that Med I, as defined by previous physiologic and pharmacologic criteria, is not a single molecule. Expand
Synthesis and biological activity of 9-deoxo-9-methylene and related prostaglandins.
9-Deoxo-16,16-dimethyl-9-methylene-PGE2 has shown efficacy for pregnancy termination by the oral and vaginal routes of administration, as well as relative freedom from gastrointestinal side effects. Expand
Inhibition of human platelet thromboxane synthetase by 11a-carbathromboxane A2 analogs.
The three 11a-carba analogs were devoid of either agonist or antagonist activity on rat aortic strips, suggesting that the thromboxane A 2 receptor in platelets exhibits different binding characteristics than the thROMboxane receptor in vascular smooth muscle. Expand
Immunoaffinity resin for purification of urinary leukotriene E4.
There was a good correlation between urinary LTE4 levels measured without purification compared to after immunoaffinity purification, and the high y-intercept of 179 indicates the presence of interfering substances in unpurified urine. Expand
Synthesis of 15R-PGD2: a potential DP2 receptor agonist.
15R-PGD(2), a potential DP(2) receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory diseases. Expand
The synthesis of 11a-carbathromboxane A2
Abstract The chemically stable thromboxane analog 11a-carbathromboxane A 2 ( 1 ) was synthesized from PGA 2 in 12 steps. 11a-Carba-TXA 2 inhibits PGH 2 -induced aggregation of human platelets.