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α1Acid glycoprotein expression in human leukocytes: Possible correlation between α1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis
- T. Nakamura, P. Board, K. Matsushita, H. Tanaka, T. Matsuyama, Takemasa Matsuda
- 1 February 1993
Abstractα-Acid glycoprotein is an acute-phase reactant that becomes markedly elevated in serum during inflammation and has an immunosuppressive effect on lymphocyte fonctions. Patients with collagen… Expand
Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis.
alpha 1-Acid glycoprotein is an acute-phase reactant that becomes markedly elevated in serum during inflammation and has an immunosuppressive effect on lymphocyte functions. Patients with collagen… Expand
Osteoclast-like cells in an in vitro model of bone destruction by rheumatoid synovium.
OBJECTIVE Osteoclasts may be involved in the process of rheumatoid bone destruction. To test this hypothesis, we developed an in vitro model of bone destruction by osteoclast-like cells derived from… Expand
Effectiveness of anti-folate receptor beta antibody conjugated with truncated Pseudomonas exotoxin in the targeting of rheumatoid arthritis synovial macrophages.
- R. Nagayoshi, T. Nagai, +7 authors T. Matsuyama
- Medicine, Biology
- Arthritis and rheumatism
- 1 September 2005
OBJECTIVE To define the distribution of folate receptor beta (FRbeta)-expressing cells in various tissues, including rheumatoid arthritis (RA) synovial tissues, and to verify the effects of an… Expand
Benign and Malignant Oncocytoma of the Salivary Glands with an Immunohistochemical Evaluation of Ki-67
We present two cases of benign oncocytoma derived from the parotid gland and minor salivary gland and one case of malignant oncocytoma from the parotid gland. The proliferative activity of the tumor… Expand
In vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor beta on the activation and proliferation of rheumatoid arthritis synovial cells.
OBJECTIVE To investigate the effects of the recombinant immunotoxin dsFv anti-FRbeta-PE38, which consists of the disulfide-stabilized Fv fragment (dsFv) of the anti-folate receptor beta (anti-FRbeta)… Expand
Programmed death-1 (PD-1)/PD-1 ligand pathway-mediated immune responses against human T-lymphotropic virus type 1 (HTLV-1) in HTLV-1-associated myelopathy/tropical spastic paraparesis and carriers…
Human T-lymphotropic virus-1 (HTLV-1) causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia-lymphoma in individuals with dysfunctional immune responses.… Expand
IL-2-induced growth of CD8+ T cell prolymphocytic leukemia cells mediated by NF-κB induction and IL-2 receptor α expression
Abstract The binding of interleukin-2 (IL-2) to its receptor on normal T cells induces nuclear expression of nuclear factor κB (NF-κB), activation of the IL-2 receptor (IL-2R) α chain gene, and cell… Expand
NF-κB involvement in the activation of primary adult T-cell leukemia cells and its clinical implications
Abstract The HTLV-I provirus-encoded Tax protein induces NF-κB in Tax-transfected Jurkat T cells or HTLVL-I- infected T cells in vitro. Tax induction of NF-κB is presumed to be involved in… Expand
Soluble CD22 as a tumor marker for hairy cell leukemia.
- K. Matsushita, I. Margulies, M. Onda, Satoshi Nagata, M. Stetler-Stevenson, R. Kreitman
- 15 September 2008
CD22 is an important immunotherapeutic target on B-cell malignancies, particularly hairy cell leukemia (HCL), but its soluble extracellular domain, sCD22, has not yet been reported in the blood. By… Expand