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Interleukin-2 and regulatory T cells in graft-versus-host disease.
- J. Koreth, K. Matsuoka, +15 authors R. Soiffer
- The New England journal of medicine
- 30 November 2011
BACKGROUND Dysfunction of regulatory T (Treg) cells has been detected in diverse inflammatory disorders, including chronic graft-versus-host disease (GVHD). Interleukin-2 is critical for Treg cell… Expand
Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease
- K. Matsuoka, J. Koreth, +12 authors J. Ritz
- Biology, Medicine
- Science Translational Medicine
- 3 April 2013
Regulatory T cell homeostasis is restored in patients with chronic graft-versus-host disease who receive low-dose interleukin-2 therapy. Restoring Balance to the Immune System Hematopoietic stem cell… Expand
Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation.
- K. Matsuoka, H. Kim, +9 authors J. Ritz
- Biology, Medicine
- The Journal of clinical investigation
- 3 May 2010
CD4+CD25+Foxp3+ Tregs have an indispensable role in the maintenance of tolerance after allogeneic HSC transplantation (HSCT). Patients with chronic graft-versus-host disease (GVHD) have fewer… Expand
Pretransplantation Anti-CCR4 Antibody Mogamulizumab Against Adult T-Cell Leukemia/Lymphoma Is Associated With Significantly Increased Risks of Severe and Corticosteroid-Refractory Graft-Versus-Host…
- S. Fuji, Y. Inoue, +12 authors T. Fukuda
- Journal of clinical oncology : official journal…
- 27 September 2016
PURPOSE Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is one important treatment option for patients with aggressive adult T-cell leukemia/lymphoma (ATLL). Mogamulizumab (anti-CCR4… Expand
Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells.
Dendritic cells (DCs) can be classified into 2 distinct subsets: conventional DCs (cDCs) and plasmacytoid DCs (pDCs). cDCs can prime antigen-specific T-cell immunity, whereas in vivo function of pDCs… Expand
Fetal tolerance to maternal antigens improves the outcome of allogeneic bone marrow transplantation by a CD4+ CD25+ T-cell-dependent mechanism.
- K. Matsuoka, T. Ichinohe, D. Hashimoto, S. Asakura, M. Tanimoto, T. Teshima
- 16 November 2005
The lack of donor availability is a major limitation to the widespread use of allogeneic hematopoietic stem cell transplantation, and therefore it would be beneficial to identify less immunogenic HLA… Expand
Fetal-maternal microchimerism: impact on hematopoietic stem cell transplantation.
- T. Ichinohe, T. Teshima, K. Matsuoka, E. Maruya, Hiroh Saji
- Medicine, Biology
- Current opinion in immunology
- 1 October 2005
Reciprocal cell traffic between mother and fetus during pregnancy gives rise to postpartum fetal-maternal lymphohematopoietic microchimerism, which is frequently detected in blood or tissue from… Expand
PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy.
CD4+Foxp3+ regulatory T cells (Tregs) play a central role in the maintenance of immune tolerance after hematopoietic stem cell transplantation. We previously reported that low-dose interleukin-2… Expand
Low telomerase activity in CD4+ regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation.
CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) play an important role in the control of chronic graft-versus-host disease (cGVHD). In this study, we examined telomere length and telomerase activity… Expand
Low-dose interleukin-2 as a modulator of Treg homeostasis after HSCT: current understanding and future perspectives
- K. Matsuoka
- International Journal of Hematology
- 1 February 2018
CD4+CD25+Foxp3+ Treg is a functionally distinct subset of mature T cells with broad suppressive activity and has been shown to play an important role in the establishment of immune tolerance after… Expand