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Marine natural products. XXXIV. Trisindoline, a new antibiotic indole trimer, produced by a bacterium of Vibrio sp. separated from the marine sponge Hyrtios altum.
A new antibiotic indole trimer was isolated, together with a known dioxopiperazine brevianamide F, from the culture of a bacterium of Vibrio sp. Expand
Synthesis of a new Cre recombinase gene based on optimal codon usage for mammalian systems.
A synthesized "mammalian Cre recombinase gene" was examined and significant increases in protein production as well as mRNA levels were observed and the recombination efficiency was compared using CHO cell transfectants having a cDNA containing loxP sites. Expand
Three new megastigmanes from the leaves of Annona muricata
Three new megastigmanes (1–3) were isolated from the leaves of Annona muricata L. (Annonaceae) together with 14 known compounds, including annoionol C, which was isolated from a natural source for the first time. Expand
Blocking of CCR5 and CXCR3 Suppresses the Infiltration of Macrophages in Acute Renal Allograft Rejection
The dual blocking of CCR5/CXCR3 can be useful in decreasing rejection, with or without CsA, and this mechanism acts, not only to block T-cell recruitment to a kidney graft but to suppress the infiltration of macrophages as well. Expand
Annonamine, a new aporphine alkaloid from the leaves of Annona muricata.
A new aporphine alkaloid named annonamine was isolated from the leaves of A. muricata L. together with four known benzylisoquinoline alkaloids and the structures were elucidated by the spectroscopic method. Expand
Bioactive compounds from the leaves of Eugenia uniflora
From the MeOH extract of the leaves of Eugenia uniflora eight compounds were isolated, including one sterol, β-sitosterol ( 1); two triterpenes, betulinic acid ( 2) and centelloside C ( 8); threeExpand
Dianthosaponins A-F, triterpene saponins, flavonoid glycoside, aromatic amide glucoside and γ-pyrone glucoside from Dianthus japonicus.
From aerial parts of Dianthus japonicus, six new and seven known oleanane-type triterpene saponins were isolated and elucidated by means of high resolution mass spectrometry, and extensive inspection of one- and two-dimensional NMR spectroscopic data. Expand
Bridelionosides A-F: Megastigmane glucosides from Bridelia glauca f. balansae.
The chemical investigation of leaves of Bridelia glauca f. balansae afforded six megastigmane glucosides, named bridelionosides A-F, along with seven known megastigmane glucosides. Their structuresExpand
Linderolides A-F, eudesmane-type sesquiterpene lactones and linderoline, a germacrane-type sesquiterpene from the roots of Lindera strychnifolia and their inhibitory activity on NO production in RAW
From the roots of Lindera strychnifolia, seven sesquiterpenes, named linderolides A-F and linderoline, were isolated together with six known compounds and lindersoline was found to be a derivative of a germacrane-type sesQUiterpene. Expand
Radical-scavenging activities of new megastigmane glucosides from Macaranga tanarius (L.) MULL.-ARG.
Four new megastigmane glucosides, named macarangiosides A-D (2-5), together with mallophenol B, lauroside E, methyl brevifolin carboxylate, and hyperin and isoquercitrin as a mixture were isolatedExpand