Diabetes-associated complications in Spontaneously Diabetic Torii fatty rats.
The Spontaneously Diabetic Torii (SDT) fatty rat is expected to be a useful model for the analysis of diabetic complications and the evaluation of drugs related to metabolic diseases.
Effect of insulin therapy on renal changes in spontaneously diabetic Torii rats.
The features of spontaneously diabetic Torii (SDT) rats indicate their usefulness as an animal model for investigating diabetic nephropathy and Glycemic control in SDT rats prevented the development of renal lesions.
Phase III Trial of Radiosensitizer PR-350 Combined With Intraoperative Radiotherapy for the Treatment of Locally Advanced Pancreatic Cancer
Although thePR-350 group did not demonstrate significantly better survival than the control group, 4 of 22 PR-350 patients were still living more than 2 years after the end of the trial, the mechanism of this increased therapeutic response to radiotherapy using PR- 350 must be clarified to establish more effective strategy for pancreatic cancer treatment.
Increased fat absorption and impaired fat clearance cause postprandial hypertriglyceridemia in Spontaneously Diabetic Torii rat.
Effects of preventing hyperphagia on glycolipid metabolic abnormalities in Spontaneously Diabetic Torii fatty rats
Spontaneously Diabetic Torii (SDT) fatty rats, made by introducing the fa allele of the Zucker fatty rat into the SDT rat genome, represent a new model of obese type 2 diabetes. SDT fatty fa/fa (SDT…
Effect of Food Restriction on Adipose Tissue in Spontaneously Diabetic Torii Fatty Rats
- H. Morinaga, T. Ohta, M. Matsushita
- Biology, MedicineInternational Journal of Experimental Diabetes…
- 19 August 2009
The results indicated that SDT fatty rat is a useful model to evaluate the functional or the morphological features in adipose tissue and develop a novel drug for antiobesity.
Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage.
It is concluded that the SDT rat is useful, as a model of non-obese insulin secretory disorder, for the analysis of the onset of type 2 diabetes and the development of antidiabetic agents.
[Clinical study on continuous 5-FU infusion for the treatment of primary liver cancer].
Handling of Missing Data in Clinical Trials: Treatment and Prevention
- K. Matsui
Points to Consider on Missing Data: Clinical Approach or Statistical Approach
- K. Matsui
Clinical approaches (e.g. LOCF) are easy to understand for physicians and are often appropriate for considering clinical background settings, but they seem to be less objective compared with statistical approaches, including multiple imputation based on “propensity score”.