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cDNA Cloning, Expression, and Functional Characterization of PI31, a Proline-rich Inhibitor of the Proteasome*
- S. McCutchen-Maloney, K. Matsuda, G. Demartino
- BiologyThe Journal of Biological Chemistry
- 16 June 2000
Results suggest that PI31 plays an important role in control of proteasome function, including that in ubiquitin-dependent pathways of protein degradation.
A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution.
Fas-mediated apoptosis in primary cultured mouse hepatocytes.
It is suggested that cultured mouse hepatocytes express protective proteins against apoptosis and that phosphorylation by PKC is also involved in protection of the hepatocytes from Fas-mediated apoptosis.
Intron retention generates a novel isoform of the murine vitamin D receptor that acts in a dominant negative way on the vitamin D signaling pathway
The present study indicates that this new VDR isoform negatively modulates the vitamin D signaling pathway, through a particular set of target genes.
Dihydropyrimidinase deficiency and severe 5-fluorouracil toxicity.
- A. V. van Kuilenburg, R. Meinsma, A. V. van Gennip
- BiologyClinical cancer research : an official journal of…
- 1 October 2003
It is demonstrated for the first time that in one patient the severe toxicity, after a treatment with 5FU, was attributable to a partial deficiency of DHP.
Crocetin, a Carotenoid from Gardenia jasminoides Ellis, Protects against Hypertension and Cerebral Thrombogenesis in Stroke‐prone Spontaneously Hypertensive Rats
The results strongly suggest that the antihypertensive and antithrombotic effects of crocetin were related to an increase in bioavailable NO, possibly mediated by decreased inactivation of NO by reactive oxygen species.
Dihydropyrimidinase deficiency: structural organization, chromosomal localization, and mutation analysis of the human dihydropyrimidinase gene.
Mutation analysis of genomic DNA in one symptomatic and five asymptomatic individuals presenting with dihydropyrimidinuria showed that all mutations reduced enzyme activity significantly, indicating that these are crucial DHP deficiency-causing mutations.
ERC-55, a binding protein for the papilloma virus E6 oncoprotein, specifically interacts with vitamin D receptor among nuclear receptors.
This work isolated a mouse Ca(2+)-binding protein (designated as VAF1) specifically interacting in vivo and in vitro with VDR among nuclear receptors like RAR, RXR, ER and GR and seems a putative VDR-specific cofactor modulating its function.
The mature size of rat 4-aminobutyrate aminotransferase is different in liver and brain.
- Y. Kontani, S. Sakata, K. Matsuda, T. Ohyama, K. Sano, N. Tamaki
- Biology, ChemistryEuropean journal of biochemistry
- 15 August 1999
The amino acid sequence predicted from a rat liver cDNA library indicated that the precursor of beta-AlaAT I consists of a mature enzyme of 466 amino acid residues and a 34-amino acid terminal segment, with amino acids attributed to the leader peptide.