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RGS Expression Rate-Limits Recovery of Rod Photoresponses
Signaling through G protein-coupled receptors (GPCRs) underlies many cellular processes, yet it is not known which molecules determine the duration of signaling in intact cells. Two candidates are GExpand
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Mutations in GNAL cause primary torsion dystonia
Dystonia is a movement disorder characterized by repetitive twisting muscle contractions and postures. Its molecular pathophysiology is poorly understood, in part owing to limited knowledge of theExpand
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GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes
Interaction of RGS proteins with orphan GPCRs promotes signaling compartmentalization and specificity.
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Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site.
The crystal structure of Thermus thermophilus elongation factor G (EF-G) carrying the point mutation His573Ala was determined at a resolution of 2.8 A. The mutant has a more closed structure thanExpand
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Human Immunodeficiency Virus Protein Tat Induces Synapse Loss via a Reversible Process That Is Distinct from Cell Death
Human immunodeficiency virus (HIV)-1 infection of the CNS produces changes in dendritic morphology that correlate with cognitive decline in patients with HIV-1 associated dementia (HAD). Here, weExpand
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The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling
G protein-coupled receptor signaling pathways mediate the transmission of signals from the extracellular environment to the generation of cellular responses, a process that is critically importantExpand
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Pharmacogenomics of GPCR Drug Targets
Summary Natural genetic variation in the human genome is a cause of individual differences in responses to medications and is an underappreciated burden on public health. Although 108Expand
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Retina-Specific GTPase Accelerator RGS11/Gβ5S/R9AP Is a Constitutive Heterotrimer Selectively Targeted to mGluR6 in ON-Bipolar Neurons
Members of the R7 family of the regulators of G-protein signaling (R7 RGS) proteins form multi-subunit complexes that play crucial roles in processing the light responses of retinal neurons. TheExpand
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The Membrane Anchor R7BP Controls the Proteolytic Stability of the Striatal Specific RGS Protein, RGS9-2*♦
A member of the RGS (regulators of G protein signaling) family, RGS9-2 is a critical regulator of G protein signaling pathways that control locomotion and reward signaling in the brain. RGS9-2 isExpand
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Targeting of RGS7/Gβ5 to the Dendritic Tips of ON-Bipolar Cells Is Independent of Its Association with Membrane Anchor R7BP
Complexes of regulator of G-protein signaling (RGS) proteins with G-protein β5 (Gβ5) subunits are essential components of signaling pathways that regulate the temporal characteristics of light-evokedExpand
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