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RGS Expression Rate-Limits Recovery of Rod Photoresponses
Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site.
The crystal structure of Thermus thermophilus elongation factor G (EF-G) carrying the point mutation His573Ala was determined and the structure of domain III is now fully visible and reveals the double split beta-alpha-beta motif also observed for EF-G domain V and for several ribosomal proteins.
Mutations in GNAL cause primary torsion dystonia
Using exome sequencing in two families with PTD, a new causative gene, GNAL, is identified with a nonsense mutation encoding p.Ser293* resulting in a premature stop codon in one family and a missense mutation encode p.Val137Met in the other.
Human Immunodeficiency Virus Protein Tat Induces Synapse Loss via a Reversible Process That Is Distinct from Cell Death
The results suggest that the impaired network function and decreased neuronal survival produced by Tat involve distinct mechanisms and that pharmacologic targets, such as LRP, might prove useful in restoring function in HAD patients.
GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes
Interaction of RGS proteins with orphan GPCRs promotes signaling compartmentalization and specificity and increases the likelihood of drug-like properties in response to EMTs.
Pharmacogenomics of GPCR Drug Targets
The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling
- Garret R. Anderson, E. Posokhova, K. Martemyanov
- Biology, ChemistryCell Biochemistry and Biophysics
- 12 June 2009
This review summarizes the current understanding of the biology of the R7 RGS complexes including their structure/functional organization, protein–protein interactions, and physiological roles.
Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors
- I. Masuho, O. Ostrovskaya, Grant M. Kramer, Christopher D. Jones, Keqiang Xie, K. Martemyanov
- BiologyScience Signaling
- 1 December 2015
The observations suggest that the diversity of the effects of GPCRs on cellular physiology may be determined by their differential engagement of multiple G proteins, coupling to which produces signals with varying signal magnitudes and activation kinetics, properties that may be exploited pharmacologically.
Retina-Specific GTPase Accelerator RGS11/Gβ5S/R9AP Is a Constitutive Heterotrimer Selectively Targeted to mGluR6 in ON-Bipolar Neurons
Electrophysiological recordings of the light response in mouse rod ON-bipolar cells reveal that the genetic elimination of RGS11 has little effect on the deactivation of Gαo in dark-adapted cells or during adaptation to background light, and suggest that the de activation of mGluR6 cascade during the light responded may require the contribution of multiple GTPase activating proteins.
The Membrane Anchor R7BP Controls the Proteolytic Stability of the Striatal Specific RGS Protein, RGS9-2*♦
- Garret R. Anderson, A. Semenov, Joseph H. Song, K. Martemyanov
- BiologyJournal of Biological Chemistry
- 16 February 2007
It is found that co-expression with R7BP dramatically elevates the levels of RGS9-2 and its constitutive subunit, Gβ5, and markedly reduces the rate of R GS9- 2·Gβ5 proteolysis.