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Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice
Huntington disease (HD), an autosomal dominant, progressive neurodegenerative disorder, is caused by an expanded CAG repeat sequence leading to an increase in the number of glutamine residues in theExpand
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Proestrous compared to diestrous wildtype, but not estrogen receptor beta knockout, mice have better performance in the spontaneous alternation and object recognition tasks and reduced anxiety-like
17beta-Estradiol (E(2)) may influence cognitive and/or affective behavior in part via the beta isoform of the estrogen receptor (ERbeta). Endocrine status and behavior in cognitive (objectExpand
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MSH3 Polymorphisms and Protein Levels Affect CAG Repeat Instability in Huntington's Disease Mice
Expansions of trinucleotide CAG/CTG repeats in somatic tissues are thought to contribute to ongoing disease progression through an affected individual's life with Huntington's disease or myotonicExpand
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Exploratory activity and fear conditioning abnormalities develop early in R6/2 Huntington's disease transgenic mice.
The Huntington's disease R6/2 transgenic mouse model, containing exon 1 of the human huntingtin gene with a greatly increased CAG repeat length, shows multiple effects of the altered polyglutamine inExpand
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Regulation of pelvic patch water flow in Bufo marinus: role of bladder volume and ANG II.
This report examines the importance of bladder volume in regulating cutaneous water uptake (Jv, cm3.cm-2.s-1 x 10(-7)) across the ventral pelvic patch and examines the role of angiotensin II (ANG II)Expand
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Early exploratory behavior abnormalities in R6/1 Huntington's disease transgenic mice
The Huntington's disease (HD) R6/1 transgenic mouse model, containing a human huntington gene exon-1 with approximately 115 CAG repeats, has multiple biochemical and neuroanatomical abnormalities.Expand
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Instability of the CAG repeat in immortalized fibroblast cell cultures from Huntington's Disease transgenic mice
Huntington's Disease transgenic mice were used for an exploration into the stability of a trinucleotide repeat. The brain shows heterogeneous somatic instability that increases quantitatively withExpand
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An early-onset congenic strain of the motor neuron degeneration (mnd) mouse.
The mouse mutant motor neuron degeneration (mnd/mnd) has been proposed as a model of neuronal ceroid lipofuscinosis (NCL) on the basis of widespread abnormal accumulating lipopigment and neuronal andExpand
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The development of swimming behavior in the neurological mutant weaver mouse.
Weaver (wv/wv) mice have well-specified ontogenetic defects in both the cerebellum and striatum, but have not previously been evaluated systematically for patterns of motor development. In thisExpand
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Transcriptional dysregulation of inflammatory/immune pathways after active vaccination against Huntington's disease.
Immunotherapy, both active and passive, is increasingly recognized as a powerful approach to a wide range of diseases, including Alzheimer's and Parkinson's. Huntington's disease (HD), an autosomalExpand
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