• Publications
  • Influence
Histamine levels and clonic convulsions of electrically-induced seizure in mice: the effects of α-fluoromethylhistidine and metoprine
The results suggest that the histaminergic neuron system is important in inhibition of the duration of clonic convulsion on electrically induced seizure in mice. Expand
Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7.
It is demonstrated that unlike HIV-1, HHV-6 andHHV-7 infections do not require expression of CXCR4 or CCR5, whereas marked down-regulation of CxCR4 is induced by these viruses, suggesting that HHV"-6 and HHV -7 infections may render CD4+ T lymphocytes resistant to T lymphocyte-tropic HIV- 1 infection. Expand
Oral administration of Enterococcus faecalis FK-23 suppresses Th17 cell development and attenuates allergic airway responses in mice.
The oral administration of LFK suppresses the asthmatic response and is associated with attenuation of Th17 cell development, a subset of CD4+ T cells implicated as having an important role in the development of several allergic disorders. Expand
Recent advances in molecular pharmacology of the histamine systems: organic cation transporters as a histamine transporter and histamine metabolism.
Histamine is inactivated by the histamine-metabolizing enzyme histamine N-methyltransferase (HNMT) in bronchus, kidney, and the central nervous system. HNMT seems to be localized in the cytoplasm,Expand
Clobenpropit (VUF-9153), a new histamine H3 receptor antagonist, inhibits electrically induced convulsions in mice.
The findings suggest that the effect of clobenpropit on electrically induced convulsions is due to an increase in endogenous histamine release in the brain, which is consistent with biochemical results that clobanpropit increased brain histidine decarboxylase activity dose dependently. Expand
Effects of alpha-fluoromethylhistidine on sleep-waking parameters in rats.
The influence of FMH seemed to be divided into direct, immediate action and late, prolonged action (decrease of W), and the results obtained support the histamine arousal hypothesis. Expand
Simultaneous electrochemical measurement method of histamine and N(τ)-methylhistamine by high-performance liquid chromatography-amperometry with o-phthalaldehyde-sodium sulfite derivatization.
An electrochemical detection method for analyzing sub-micro amounts of histamine and N(τ)-methylhistamine in biological samples by high-performance liquid chromatography (HPLC)-amperometry confirms not only the sensitivity and specificity of the assay but also the potential and convenience it offers to laboratory work, especially in the analysis of the regulation of histaminergic neurons. Expand
Effect of alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase, on histamine levels in mouse tissues.
It is concluded that α-FMH causes depletion of newly synthesized histamine in situ and, thus, is useful for studies on histamine. Expand
Systematic Method to Obtain Novel Genes That Are Regulated bymi Transcription Factor: Impaired Expression of Granzyme B and Tryptophan Hydroxylase in mi/mi Cultured Mast Cells
To obtain new genes whose transcription may be regulated by MITF, a subtracted cDNA library was prepared using +/+ and mi/mi CMCs and the +-MITF bound three and one CANNTG motifs in the Gr B and TPH promoters, respectively, and transactivated these two genes, indicating the involvement of MITF in their expression. Expand
Activation of peroxisome proliferator‐activated receptor gamma suppresses mast cell maturation involved in allergic diseases
The role of PPARγ in regulating bone marrow‐derived mast cell maturation and the therapeutic implications for mast cell‐related diseases such as atopic or contact dermatitis are investigated. Expand