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Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty
The presence of obesity increases the risk of thrombotic vascular diseases. The role of fat accumulation and its effect on plasminogen activator inhibitor–1 (PAI–1) levels was investigated in humansExpand
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Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
The adipocyte fatty-acid–binding protein, aP2, has an important role in regulating systemic insulin resistance and lipid metabolism. Here we demonstrate that aP2 is also expressed in macrophages, hasExpand
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Adipocyte-Derived Plasma Protein Adiponectin Acts as a Platelet-Derived Growth Factor-BB–Binding Protein and Regulates Growth Factor–Induced Common Postreceptor Signal in Vascular Smooth Muscle Cell
Background—Vascular smooth muscle cell proliferation plays an important role in the development of atherosclerosis. We previously reported that adiponectin, an adipocyte-specific plasma protein,Expand
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Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy.
Adult stem cells hold great promise for use in tissue repair and regeneration, and the delivery of autologous progenitor cells into ischemic tissue is emerging as a novel therapeutic option. We andExpand
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A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance.
We and others (1–9) have shown that the accumulation of visceral fat is associated with multiple risk factor syndrome more closely than with the BMI itself or the amount of subcutaneous fat. In theseExpand
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Adiponectin Replenishment Ameliorates Obesity-Related Hypertension
Patients with obesity are susceptible to hypertension. We have reported that the plasma adiponectin levels are decreased in obesity and that adiponectin has many defensive properties againstExpand
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Combined Adipocyte-Macrophage Fatty Acid–Binding Protein Deficiency Improves Metabolism, Atherosclerosis, and Survival in Apolipoprotein E–Deficient Mice
Background—The adipocyte fatty acid–binding protein (FABP) aP2 is expressed by adipocytes and macrophages and modulates insulin resistance, glucose and lipid metabolism, and atherosclerosis. InsulinExpand
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Correlation between plasma levels of glutamate, alanine and serine with severity of depression
The goal of this study was to evaluate the utility of using plasma levels of amino acids as an indicator of the severity of depression. The samples were collected from 23 depressed patients receivingExpand
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Disturbed secretion of mutant adiponectin associated with the metabolic syndrome.
Adiponectin, an adipocyte-derived protein, consists of collagen-like fibrous and complement C1q-like globular domains, and circulates in human plasma in a multimeric form. The protein exhibitsExpand
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Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction
Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties. The present observational study focused on the relation between serumExpand
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