A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis
- K. Machiels, M. Joossens, S. Vermeire
- Medicine, BiologyGut
- 10 September 2013
The composition of the fecal microbiota of UC patients differs from that of healthy individuals: the authors found a reduction in R hominis and F prausnitzii, both well-known butyrate-producing bacteria of the Firmicutes phylum, suggesting that different bacterial species contribute to the pathogenesis of UC and CD.
A microbial signature for Crohn's disease
- V. Pascal, M. Pozuelo, C. Manichanh
- Medicine, BiologyGut
- 18 January 2017
The results showed that UC and CD are two distinct subtypes of IBD at the microbiome level, and for the first time, microbiomarkers to discriminate between CD and non-CD independently of geographical regions are proposed.
Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD
- J. Sabino, S. Vieira-Silva, J. Raes
- Medicine, BiologyGut
- 20 May 2016
The first report of PSC-associated faecal dysbiosis, independent from IBD signatures, is presented, suggesting the intestinal microbiota could be a contributing factor in PSC pathogenesis.
Mucosal Gene Expression of Cell Adhesion Molecules, Chemokines, and Chemokine Receptors in Patients With Inflammatory Bowel Disease Before and After Infliximab Treatment
- I. Arijs, G. Hertogh, P. Rutgeerts
- Medicine, BiologyAmerican Journal of Gastroenterology
- 1 April 2011
Infliximab therapy restored the upregulations of leukocyte CAMs in IBDc responders to infliximab that paralleled the disappearance of the inflammatory cells from the colonic lamina propria, showing that at least part of the mechanism of anti-tumor necrosis factor-α therapy goes through downregulation of certain adhesion molecules.
Donor Species Richness Determines Faecal Microbiota Transplantation Success in Inflammatory Bowel Disease.
- S. Vermeire, M. Joossens, J. Raes
- MedicineJournal of Crohn's & Colitis
- 1 April 2016
Faecal microbiota transplantation with donor prescreening led to endoscopic and long-term (>2 years) remission in 2 out of 8 ulcerative colitis patients and higher donor richness was associated with successful transplant.
Butyricicoccus pullicaecorum in inflammatory bowel disease
- V. Eeckhaut, K. Machiels, F. Van Immerseel
- Medicine, BiologyGut
- 22 December 2012
Patients with inflammatory bowel disease have lower numbers of Butyricicoccus bacteria in their stools and administration of B pullicaecorum attenuates TNBS-induced colitis in rats and supernatant of B pulledicaECorum cultures strengthens the epithelial barrier function by increasing the TER.
Effect of vedolizumab (anti-α4β7-integrin) therapy on histological healing and mucosal gene expression in patients with UC
- I. Arijs, G. De Hertogh, S. Vermeire
- MedicineGut
- 7 October 2016
VDZ induces histological healing in >50% of patients with endoscopic healing, with maximal effect at week 52, and restored, although incompletely, the colonic expression of many immune-related genes in patients with UC achieving endoscopic healers at weeks 52.
Early Postoperative Endoscopic Recurrence in Crohn’s Disease Is Characterised by Distinct Microbiota Recolonisation
- K. Machiels, M. Pozuelo Del Río, S. Vermeire
- MedicineJournal of Crohn's & Colitis
- 25 April 2020
Microbiota recolonisation after ileocaecal resection is different between recurrence and non-recurrence patients, with Fusobacteria as the most prominent player driving early POR.
Faecal metabolite profiling identifies medium-chain fatty acids as discriminating compounds in IBD
- V. De Preter, K. Machiels, K. Verbeke
- Medicine, BiologyGut
- 8 May 2014
Faecal metabolic profiling in patients with IBD relative to healthy controls identified MCFAs as important metabolic biomarkers of disease-related changes.
Specific members of the predominant gut microbiota predict pouchitis following colectomy and IPAA in UC
- K. Machiels, J. Sabino, S. Vermeire
- MedicineGut
- 30 September 2015
Pouchitis is the most common complication after colectomy with ileal pouch-anal anastomosis for UC and the risk is the highest within the 1st year after surgery, so it is hypothesised that the risk for pouchitis can be predicted based on the faecal microbial composition before coLECTomy.
...
...