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Farnesol-induced generation of reactive oxygen species via indirect inhibition of the mitochondrial electron transport chain in the yeast Saccharomyces cerevisiae.
- K. Machida, T. Tanaka, K. Fujita, M. Taniguchi
- Medicine, Biology
- Journal of bacteriology
- 1 September 1998
The present study supports the idea that FOH inhibits the ability of the electron transport chain to accelerate ROS production via interference with a phosphatidylinositol type of signal. Expand
Suppression of Apoptosis by Cyclophilin D via Stabilization of Hexokinase II Mitochondrial Binding in Cancer Cells*
It is proposed here that cyclophilin D suppresses apoptotic cell death via a mitochondrial hexokinase II-dependent mechanism in cancer cells. Expand
Farnesol-induced growth inhibition in Saccharomyces cerevisiae by a cell cycle mechanism.
An interference with a phosphatidylinositol-type signalling which is involved in cell cycle progression as a cause of FOH-induced growth inhibition in yeast cells is proposed. Expand
MT-21 is a synthetic apoptosis inducer that directly induces cytochrome c release from mitochondria.
MT-21 is a possible candidate antitumor agent that is able to induce apoptosis via the direct release of cytochrome c from the mitochondria through the activation mechanism of caspase-3, an important cysteine aspartic protease during MT-21-induced apoptosis. Expand
Farnesol‐induced generation of reactive oxygen species dependent on mitochondrial transmembrane potential hyperpolarization mediated by F0F1‐ATPase in yeast
An isoprenoid farnesol (FOH) inhibited cellular oxygen consumption and induced mitochondrial generation of reactive oxygen species (ROS) in cells of Saccharomyces cerevisiae in correlation with… Expand
A Novel Adenine Nucleotide Translocase Inhibitor, MT-21, Induces Cytochrome c Release by a Mitochondrial Permeability Transition-independent Mechanism*
Although ANT resides in the mitochondrial inner membrane, specific ANT inhibitors can induce cytochrome c release without having an effect on inner membrane permeability, suggesting that MT-21 can be a powerful tool for studying the mechanism of PT-independent cytochromec release from mitochondria. Expand
Long-chain alkyl ester of AMP acts as an antagonist of glucose-induced signal transduction that mediates activation of plasma membrane proton pump in Saccharomyces cerevisiae.
Results implied that AMPC16 caused a Mg(2+)-dependent cytotoxic effect on Sac. Expand
Protective effect of antioxidants against para-nonylphenol-induced inhibition of cell growth in Saccharomyces cerevisiae.
- Y. Okai, K. Higashi-Okai, +6 authors M. Taniguchi
- Biology, Medicine
- FEMS microbiology letters
- 1 April 2000
NP did not show a significant inhibitory effect on cell growth and survival of mitochondria-deficient petite mutant cells and they showed a relatively weak ROS-generating activity compared with parent yeast cells, suggesting that NP-induced inhibition ofcell growth and oxygen consumption in S. cerevisiae might be possibly associated with ROS generation in yeast mitochondria. Expand
Molecular Interaction between Cyclophilin D and Adenine Nucleotide Translocase in Cytochrome c Release
It is shown here that the modification of adenine nucleotide translocase (ANT), which is one of the components of MPTP, can induce two different types of the cytochrome c release. Expand
Identification of Saccharomyces cerevisiae Isoleucyl-tRNA Synthetase as a Target of the G1-specific Inhibitor Reveromycin A*
- Y. Miyamoto, K. Machida, +8 authors T. Miyakawa
- Biology, Medicine
- The Journal of Biological Chemistry
- 9 August 2002
Results indicated that IleRS is a target of RM-A in vivo, and a defect of the GCN2 gene led to decreasedRM-A resistance. Expand