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Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells
iILC2 are potent inducers of airway inflammation in response to acute house dust mite challenge and a novel role for Notch signaling is revealed in eliciting ILC2 plasticity and driving the emergence of highly proinflammatory innate lymphocytes.
IgM Production by Bone Marrow Plasmablasts Contributes to Long-Term Protection against Intracellular Bacterial Infection
It is demonstrated that chronic infection with the intracellular bacterium Ehrlichia muris elicits a protective, long-term IgM response, and a population of CD138highIgMhigh B cells responsible for Ag-specific IgM production in the bone marrow is identified.
Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B.
It is shown that dysfunction of aged marrow macrophages (Mφs) directs HSC platelet-bias, and the therapeutic potential of their manipulation as antigeronic targets is revealed.
Transient Activation of Hematopoietic Stem and Progenitor Cells by IFNγ during Acute Bacterial Infection
In response to inflammatory signals elicited during acute infection, hematopoietic stem cells can undergo a rapid, IFNγ-dependent, transient shift from dormancy to activity, ostensibly, to provide the host with additional or better-armed innate cells for host defense.
Infection-Induced Myelopoiesis during Intracellular Bacterial Infection Is Critically Dependent upon IFN-γ Signaling
It is proposed that, in addition to its many other known roles, IFN-γ acts to control infection by directly promoting the differentiation of myeloid cells that contribute to host defense.
T-Cell-Independent Humoral Immunity Is Sufficient for Protection against Fatal Intracellular Ehrlichia Infection
- C. Bitsaktsis, B. Nandi, R. Racine, K. MacNamara, G. Winslow
- Biology, MedicineInfection and Immunity
- 30 July 2007
A major protective role for classical T-cell-independent humoral immunity during an intracellular bacterial infection is highlighted, as shown by the fact that E. muris immunization was effective in CD4-, CD8-, and major histocompatibility complex (MHC) class II-deficient mice.
An Immature Myeloid/Myeloid-Suppressor Cell Response Associated with Necrotizing Inflammation Mediates Lethal Pulmonary Tularemia
- S. Periasamy, D. Avram, Amanda McCabe, K. MacNamara, T. Sellati, J. Harton
- Biology, MedicinePLoS pathogens
- 1 March 2016
E evaluation of the sequential and systemic host immune response in pulmonary tularemia reveals that in contrast to overwhelming bacterial burden or cytokine production, an overt innate cellular response to Ft drives tissue pathology and host mortality.
MyD88 Signaling in CD4 T Cells Promotes IFN-γ Production and Hematopoietic Progenitor Cell Expansion in Response to Intracellular Bacterial Infection
- Yubin Zhang, Maura Jones, Amanda McCabe, G. Winslow, D. Avram, K. MacNamara
- Biology, MedicineJournal of Immunology
- 1 May 2013
An essential role for CD4 T cells in mediating HSPC activation in response to bacterial infection is demonstrated and a novel role for MyD88 signaling in CD4T cells is illustrated in this process, further support the idea that IFN-γ production is essential for HSPCs activation and hematopoietic responses to infection.
Macrophages: Key regulators of steady-state and demand-adapted hematopoiesis.
Diminished Hematopoietic Activity Associated with Alterations in Innate and Adaptive Immunity in a Mouse Model of Human Monocytic Ehrlichiosis
- K. MacNamara, R. Racine, Madhumouli Chatterjee, D. Borjesson, G. Winslow
- Medicine, BiologyInfection and Immunity
- 18 May 2009
It is proposed that inflammation associated with ehrlichia infection suppresses bone marrow function, induces the emigration of B cells, and establishes hematopoietic activity in the spleen, which are also responsible in part for blood cytopenias and other clinical features of HME.