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T-Cell-Independent Humoral Immunity Is Sufficient for Protection against Fatal Intracellular Ehrlichia Infection
TLDR
A major protective role for classical T-cell-independent humoral immunity during an intracellular bacterial infection is highlighted, as shown by the fact that E. muris immunization was effective in CD4-, CD8-, and major histocompatibility complex (MHC) class II-deficient mice. Expand
IgM Production by Bone Marrow Plasmablasts Contributes to Long-Term Protection against Intracellular Bacterial Infection
TLDR
It is demonstrated that chronic infection with the intracellular bacterium Ehrlichia muris elicits a protective, long-term IgM response, and a population of CD138highIgMhigh B cells responsible for Ag-specific IgM production in the bone marrow is identified. Expand
Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells
TLDR
iILC2 are potent inducers of airway inflammation in response to acute house dust mite challenge and a novel role for Notch signaling is revealed in eliciting ILC2 plasticity and driving the emergence of highly proinflammatory innate lymphocytes. Expand
An Immature Myeloid/Myeloid-Suppressor Cell Response Associated with Necrotizing Inflammation Mediates Lethal Pulmonary Tularemia
TLDR
E evaluation of the sequential and systemic host immune response in pulmonary tularemia reveals that in contrast to overwhelming bacterial burden or cytokine production, an overt innate cellular response to Ft drives tissue pathology and host mortality. Expand
Transient Activation of Hematopoietic Stem and Progenitor Cells by IFNγ during Acute Bacterial Infection
TLDR
In response to inflammatory signals elicited during acute infection, hematopoietic stem cells can undergo a rapid, IFNγ-dependent, transient shift from dormancy to activity, ostensibly, to provide the host with additional or better-armed innate cells for host defense. Expand
Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B.
TLDR
It is shown that dysfunction of aged marrow macrophages (Mφs) directs HSC platelet-bias, and the therapeutic potential of their manipulation as antigeronic targets is revealed. Expand
Diminished Hematopoietic Activity Associated with Alterations in Innate and Adaptive Immunity in a Mouse Model of Human Monocytic Ehrlichiosis
TLDR
It is proposed that inflammation associated with ehrlichia infection suppresses bone marrow function, induces the emigration of B cells, and establishes hematopoietic activity in the spleen, which are also responsible in part for blood cytopenias and other clinical features of HME. Expand
Impaired Germinal Center Responses and Suppression of Local IgG Production during Intracellular Bacterial Infection
TLDR
The data provide a mechanism whereby an intracellular bacterial infection can compromise local immunity to coinfecting pathogens or antigenic challenge, and organized GCs and phenotypically defined splenic GC B cells were found in lymph nodes, but not spleens. Expand
Macrophages: Key regulators of steady-state and demand-adapted hematopoiesis.
TLDR
The role of macrophages (Mϕs) is highlighted as a central regulator of both steady-state and demand-adapted hematopoiesis, and two key inflammatory proteins, interferon-γ and granulocyte-colony stimulating factor, are focused on. Expand
MyD88 Signaling in CD4 T Cells Promotes IFN-γ Production and Hematopoietic Progenitor Cell Expansion in Response to Intracellular Bacterial Infection
TLDR
An essential role for CD4 T cells in mediating HSPC activation in response to bacterial infection is demonstrated and a novel role for MyD88 signaling in CD4T cells is illustrated in this process, further support the idea that IFN-γ production is essential for HSPCs activation and hematopoietic responses to infection. Expand
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