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Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart
T-tubular invaginations of the sarcolemma of ventricular cardiomyocytes contain junctional structures functionally coupling L-type calcium channels to the sarcoplasmic reticulum calcium-releaseExpand
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Na+−Ca2+ exchange and sarcoplasmic reticular Ca2+ regulation in ventricular myocytes from transgenic mice overexpressing the Na+−Ca2+ exchanger
1 The contribution of the sarcoplasmic reticulum (SR) and Na+−Ca2+ exchanger to intracellular Ca2+ regulation in mouse cardiac myocytes was investigated by measuring contraction after variable restExpand
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Sheep cardiac sarcoplasmic reticulum calcium‐release channels: modification of conductance and gating by temperature.
1. The gating and conduction properties of single calcium‐release channels of sheep isolated cardiac junctional sarcoplasmic reticulum membranes incorporated into planar phospholipid bilayers wereExpand
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Effect of 17 beta-oestradiol on contraction, Ca2+ current and intracellular free Ca2+ in guinea-pig isolated cardiac myocytes.
1. The effect of 17 beta-oestradiol on cardiac cell contraction, inward Ca2+ current and intracellular free Ca2+ ([free Ca2+]i) was investigated in guinea-pig single, isolated ventricular myocytes.Expand
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Sodium‐dependent control of intracellular pH in Purkinje fibres of sheep heart.
Intracellular pH (pHi) of Purkinje fibres from sheep heart was recorded with pH‐sensitive glass micro‐electrodes. The cells were acidified by one of three methods: (1) exposure to and subsequentExpand
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Plant-derived estrogens relax coronary arteries in vitro by a calcium antagonistic mechanism.
OBJECTIVES To investigate the potential for plant derived estrogens (phytoestrogens) genistein, phloretin, biochanin A and zearalanone to relax rabbit coronary arteries in vitro and to determine theExpand
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Effects of acidosis on Na+/Ca2+ exchange and consequences for relaxation in guinea pig cardiac myocytes.
We investigated the effect of intracellular acidosis (imposed by NH4Cl prepulses) on the relaxation and decline in intracellular Ca2+ (using indo 1 fluorescence) of isolated cardiac myocytes from theExpand
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Overexpression of the Na(+)/Ca(2+) exchanger and inhibition of the sarcoplasmic reticulum Ca(2+)-ATPase in ventricular myocytes from transgenic mice.
BACKGROUND Myocytes from failing hearts produce slower and smaller Ca(2+) transients associated with reduction in expression of sarcoplasmic reticulum (SR) Ca(2+) ATPase and an overexpression ofExpand
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Effects of anoxia on intracellular Ca2+ and contraction in isolated guinea pig cardiac myocytes.
Single, enzymatically isolated guinea pig ventricular myocytes were exposed to 3-min periods of anoxia with glucose-free Tyrode solution containing 1 mM sodium dithionite (Na2S2O4) and were thenExpand
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Novel stimulatory actions of the phytoestrogen genistein: effects on the gain of cardiac excitation‐contraction coupling
Genistein, a phytoestrogen found abundantly in soy products, is thought to be cardioprotective, partly through its ability to act as a natural Ca2+ channel antagonist. However, the precise nature andExpand
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