K. M. Witherup

Publications13
h-index12
Citations1,180
Highly Influential Citations26
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Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes.
TLDR
The peptide was found to dose-dependently increase intracellular Ca2+ at concentrations ranging from 3 to 30 microM, and this response was not blocked by a known NT antagonist.
High Fatty Acid Content in Rabbit Serum Is Responsible for the Differentiation of Osteoblasts Into Adipocyte‐like Cells
TLDR
It is observed that rabbit serum (RS) induces adipocyte‐like differentiation in human osteosarcoma SaOS‐2/B10 and MG‐63 cell lines, in rat ROS17/2.8 and SaOS-2‐B10 cells, and in mouse calvaria‐derived osteoblastic MB1.8 cells, suggesting that fatty acids or their metabolites can initiate the switch from osteoblasts to adipocytes‐like cells.
Identification of 3-hydroxy-3-methylglutaric acid (HMG) as a hypoglycemic principle of Spanish moss (Tillandsia usneoides).
TLDR
Electroactivity-directed fractionation of an ethanol extract prepared from Tillandsia usneoides led to the isolation of four apparently bioactive compounds, identified as citric acid, succinic acid, 3-hydroxy-3-methylglutaric acid (HMG), and 3,6,3',5'-tetramethoxy-5,7,4'-trihydroxyflavone-7-O-beta-D-g lucoside.
Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation.
TLDR
Taxus needles may provide a renewable source of this valuable compound taxol and 10-deacetylbaccatin III, a related compound that can be converted to taxol through a semi-synthetic route.
1H- and 13C-nmr assignments for taxol, 7-epi-taxol, and cephalomannine.
The 1H- and 13C-nmr spectra of taxol [1], 7-epi-taxol [2], and cephalomannine [3] were assigned using modern 1D and 2D nmr methods. Preliminary conformational information was obtained by nOe…
Identification of fatty acid methyl ester as naturally occurring transcriptional regulators of the members of the peroxisome proliferator-activated receptor family
TLDR
It is determined that ethyl esters of palmitic and oleic acids are also potent activators of this receptor and fatty acid ester formation may control the cellular concentrations of fatty acids, and acyl-ester formation may play a role in the control of metabolic pathways and the activation of the PPAR.
Taxinine M, a new tetracyclic taxane from Taxus brevifolia.
Antibacterial activity of lonchocarpol A.
Lonchocarpol A, a flavanone, demonstrates in vitro inhibitory activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. This activity is antagonized…
Martinelline and Martinellic Acid, Novel G-Protein Linked Receptor Antagonists from the Tropical Plant Martinella iquitosensis (Bignoniaceae)
Design of novel, potent, noncovalent inhibitors of thrombin with nonbasic P-1 substructures: rapid structure-activity studies by solid-phase synthesis.
TLDR
Solid-phase synthesis was used to generate benzylamides of D-diphenylAlaPro by aminolysis of Boc dipeptide Kaiser resin, and the structure-activity relationships and molecular modeling suggest a unique fit of the benzyl side chain into P-1 with the meta substituent occupying the recess.
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