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Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.
- M. Avery, K. M. Muraleedharan, P. Desai, A. Bandyopadhyaya, Marise M Furtado, B. Tekwani
- Chemistry, BiologyJournal of Medicinal Chemistry
- 21 August 2003
The study suggests the possibility of developing artemisinin analogues as potential drug candidates against both malaria and leishmaniasis.
Transformation of artemisinin by Cunninghamella elegans
- I. Parshikov, K. M. Muraleedharan, M. Avery, J. Williamson
- Biology, ChemistryApplied Microbiology and Biotechnology
- 21 January 2004
7β-hydroxyartemisinin, obtained from microbial transformation, is utilized as a semi-synthetic precursor for the synthesis of novel 7β-substituted art Artemisinin anti-malarial agents.
The design and synthesis of redox core-alpha amino acid composites based on thiol-disulfide exchange mechanism and a comparative study of their zinc abstraction potential from [CCXX] boxes in proteins
Biocatalysis of the Antimalarial Artemisinin by Mucor ramannianus. Strains
- I. Parshikov, B. Miriyala, K. M. Muraleedharan, Anuradha Illendula, M. Avery, J. Williamson
- Biology, Chemistry
- 1 January 2005
Abstract Biocatalysis of artemisinin by different strains of Mucor ramannianus.* illustrates a simple approach to bioengineering for attaining useful biotransformation strains for preparative or…
Drugs for Parasitic Infections: Advances in the Discovery of New Antimalarials
Progress in the development of peroxide-based anti-parasitic agents.
Determination of antimalarial compound, ARB-89 (7β-hydroxy-artemisinin carbamate) in rat serum by UPLC/MS/MS and its application in pharmacokinetics.
Advances in the Discovery of New Antimalarials
Halo- and selenolactonisation: the two major strategies for cyclofunctionalisation
N-Methylpyrrolidone Hydroperoxide/Cs2 CO3 as an Excellent Reagent System for the Hydroxy-Directed Diastereoselective Epoxidation of Electron-Deficient Olefins.
This report introduces N-methylpyrrolidone hydroperoxide (NMPOOH)/base as an excellent reagent system for hydroxy-directed syn selective epoxidation of electron-deficient olefins, characterized by…