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Transformation of artemisinin by Cunninghamella elegans
TLDR
7β-hydroxyartemisinin, obtained from microbial transformation, is utilized as a semi-synthetic precursor for the synthesis of novel 7β-substituted art Artemisinin anti-malarial agents. Expand
The design and synthesis of redox core-alpha amino acid composites based on thiol-disulfide exchange mechanism and a comparative study of their zinc abstraction potential from [CCXX] boxes in proteins
The design and synthesis of agents that can abstract zinc from their [CCXX] (C=cysteine; X=cysteine/histidine) boxes by thioldisulfide exchange-having as control, the redox parities of the coreExpand
Drugs for Parasitic Infections: Advances in the Discovery of New Antimalarials
Malaria remains one of the deadliest diseases on this planet that accounts for 124–283 million clinical cases and up to 755 000 deaths each year. About 90% of these casualties occur in tropicalExpand
Biocatalysis of the Antimalarial Artemisinin by Mucor ramannianus. Strains
Abstract Biocatalysis of artemisinin by different strains of Mucor ramannianus.* illustrates a simple approach to bioengineering for attaining useful biotransformation strains for preparative orExpand
Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.
TLDR
The study suggests the possibility of developing artemisinin analogues as potential drug candidates against both malaria and leishmaniasis. Expand
Progress in the development of peroxide-based anti-parasitic agents.
TLDR
Progress made in the past decade pertaining to the development of anti-parasitic agents based on artemisinin is presented and an outline on its seco analogs and art Artemisinin bundles are given for a broader perspective on structure-activity relationships. Expand
Microbial transformation of artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger
TLDR
Transformation of the anti-malarial drug artemisinin by the fungi Eurotium amstelodami and Aspergillus niger were investigated and metabolites from each fungal extract were isolated and identified using mass spectrometry and nuclear magnetic resonance. Expand
Hydroxylation of 10-deoxoartemisinin by Cunninghamella elegans.
TLDR
The metabolites 2 and 4 retained an intact peroxide group and are therefore useful scaffolds for synthetic modification in the search for new antimalarial agents. Expand
Determination of antimalarial compound, ARB-89 (7β-hydroxy-artemisinin carbamate) in rat serum by UPLC/MS/MS and its application in pharmacokinetics.
TLDR
A sensitive and rapid ultra-performance liquid chromatography tandem mass spectrometry (UPLC/MS/MS) method was developed and validated and successfully used to quantitate the novel antimalarial compound ARB-89 after intravenous and oral administration to rats. Expand
Advances in the Discovery of New Antimalarials
TLDR
This chapter gives a comprehensive overview of malaria epidemiology, with particular emphasis on progress made in the drug development efforts during the last decade. Expand
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