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Analysis of platelet glycoprotein Ia (alpha2 integrin) allele frequencies in three North American populations reveals genetic association between nucleotide 807C/T and amino acid 505 Glu/Lys (HPA-5)…
- A. Reiner, K. M. Aramaki, G. Teramura, L. Gaur
- Biology, Medicine
- Thrombosis and haemostasis
- 1 September 1998
The results indicate a genetic relationship between the 807C/T and Glu/Lys505 dimorphisms that leads to an evolutionary model of GPIa isoforms. Expand
A novel isoform of platelet glycoprotein Ib alpha is prevalent in African Americans.
Analysis of HPA-2 and VNTR haplotypes demonstrated an unexpected linkage pattern in the African American population, suggesting a more complex evolutionary pattern of GPIb alpha isoforms than previously proposed. Expand
Platelet glycoprotein IIb polymorphism, traditional risk factors and non‐fatal myocardial infarction in young women
The Ser843 variant of glycoprotein IIb may be associated with an increased risk of MI in young women with other cardiovascular risk factors and additional studies involving larger numbers of subjects are needed to confirm this preliminary finding. Expand
A novel isoform of platelet glycoprotein Ibα is prevalent in African Americans
Analysis of HPA‐2 and VNTR haplotypes demonstrated an unexpected linkage pattern in the African American population, suggesting a more complex evolutionary pattern of GPIbα isoforms than previously proposed. Expand
Proteolytic modulation of thrombopoietin activity: comparison of thrombin, plasmin, and urokinase.
It is demonstrated that urokinase and plasmin also cleave rhTpo in a time-dependent manner, and these proteolytic events have potential implications for regulation of Tpo activity in vivo. Expand
Use of a PCR-based assay for fetal Cw antigen genotyping in a patient with a history of moderately severe hemolytic disease of the newborn due to anti-Cw.
This case illustrates the utility of PCR-based fetal genotype determination in pregnancies at risk of HDN due to uncommon red cell antibodies such as anti-Cw and excludes HDN in the current pregnancy, thus avoiding the need for further invasive or noninvasive diagnostic procedures. Expand