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Purification and substrate specificity of a strongly hydrophobic extracellular metalloendopeptidase ("gelatinase") from Streptococcus faecalis (strain 0G1-10).
- P. Mäkinen, D. Clewell, F. An, K. Mäkinen
- Medicine, Chemistry
- The Journal of biological chemistry
- 25 February 1989
The pronounced ability of the Zn-endopeptidase to attack collagenous materials and certain bioactive peptides suggests its participation in inflammatory processes involving the presence of S. faecalis. Expand
Measuring Dental Caries in the Mixed Dentition by ICDAS
- E. Honkala, R. Runnel, +4 authors K. Mäkinen
- International journal of dentistry
- 31 October 2011
ICDAS recording seems to give appropriate information from the occurrence of caries lesions and its correlations between the primary and permanent teeth and surfaces, suggesting that caries might be increasing in this population of primary school children. Expand
Turku sugar studies. V. Final report on the effect of sucrose, fructose and xylitol diets on the caries incidence in man.
It was suggested that the non- and anticariogenic properties of xylitol principally depend on its lack of suitability for microbial metabolism and physico-chemical effects in plaque and saliva. Expand
Effect of sorbitol, xylitol, and xylitol/sorbitol chewing gums on dental plaque.
The plaque of the subjects who used XYL and XYL/SOR gums showed a significantly better ability to resist pH drops induced by the sucrose rinse than the plaque in the SOR gum group. Expand
Turku sugar studies XI. Effects of sucrose, fructose and xylitol diets on glucose, lipid and urate metabolism.
The results suggest that the effects of peroral fructose and xylitol on the metabolic parameters studied in this investigation do not differ from that of sucrose. Expand
Similarity of the Effects ofErythritol and Xylitol on SomeRisk Factors of Dental Caries
Erythritol and xylitol may exert similar effects on some risk factors of dental caries, although the biochemical mechanism of the effects may differ. Expand
Sugar Alcohol Sweeteners as Alternatives to Sugar with Special Consideration of Xylitol
- K. Mäkinen
- Medical Principles and Practice
- 1 May 2011
Partial sugar substitution with polyols is an important dietary tool in the prevention of dental caries that should be used to enhance existing fluoride-based caries prevention programmes. Expand
Turku sugar studies XVIII. Incidence of dental caries in relation to 1-year consumption of xylitol chewing gum.
The results show a profound difference in the caries increment rate between the two experimental groups, which clearly indicate a therapeutic, caries inhibitory effect of xylitol. Expand
An endo-acting proline-specific oligopeptidase from Treponema denticola ATCC 35405: evidence of hydrolysis of human bioactive peptides.
The ready hydrolysis of human bioactive peptides at bonds involving an imino acid residue suggests that enzymes like POPase may contribute to the chronicity of periodontal infections by participating in the peptidolytic processing of those peptides. Expand
Polyol chewing gums and caries rates in primary dentition: a 24-month cohort study.
- K. Mäkinen, P. Hujoel, C. Bennett, K. Isotupa, P. Mäkinen, P. Allen
- Caries research
- 1 July 1996
The effect of 2-year chewing-gum use on the caries rates of primary teeth was studied in a combined school and home program in a sample of 510 initially 6-year-old subjects with high caries… Expand