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Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and behavioral effects.
Zolpidem [N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide hemitartrate] is reported to be a rapid onset, short duration hypnotic that interacts at the benzodiazepine recognitionExpand
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The neurochemistry of Parkinson's disease: effect of L-dopa therapy.
Post-mortem brain material from control and Parkinson's disease patients was examined to elucidate further the neurochemistry of this disease and to determine the mechanism of action of L-dopa as aExpand
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Biochemical evidence of dysfunction of brain neurotransmitters in the Lesch-Nyhan syndrome.
Different brain regions were removed post mortem from three patients with the Lesch-Nyhan syndrome and were examined for alterations in hypoxanthine-guanine phosphoribosyl transferase (HGPRT),Expand
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Parkinson's Disease: Activity of L-Dopa Decarboxylase in Discrete Brain Regions
The activity of L-dopa decarboxylase was greatly reduced in the striatum, less so in the hypothalamus, and unchanged in the cortex of brains of patients with Parkinson's disease. However, it appearsExpand
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—The enzymatic decarboxylation of l‐DOPA was measured in isotonic dextrose homogenates of different regions of the human brain by estimating 14CO2 evolved from tracer amounts of dExpand
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Chronic antidepressants and GABA "B" receptors: a GABA hypothesis of antidepressant drug action.
Amitryptyline (10 mg/kg), desipramine (5 mg/kg), citalopram (10 mg/kg) and viloxazine (10 mg/kg) were administered to rats either acutely (decapitation 1 hr after i.p. injection) or subacutely (byExpand
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Pharmacological and behavioral profile of alpidem as an anxiolytic.
Pharmacological and behavioral studies in mice and rats have shown that the imidazopyridine alpidem possesses anxiolytic activity with a profile which is substantially different from that ofExpand
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Neurobiological substrates of tardive dyskinesia: the GABA hypothesis
Recent observations indicate that the dopamine receptor supersensitivity that occurs after chronic exposure to neuroleptic drugs fails to address or explain many known features of tardive dyskinesia.Expand
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Distribution of high affinity sodium-independent [3H]gamma-aminobutyric acid ([3H]GABA) binding in the human brain: Alterations in Parkinson's disease
The regional distribution and properties of the sodium-independent "specific" binding of [3H]GABA to membranes prepared from human brains (control and Parkinsonian patients) have been investigated.Expand
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Cortical modulation of striatal function
The effect of bilateral section of the corticostriatal projections or of selective bilateral ablation of the frontal cortex on behavioral and biochemical parameters related to striatal function wereExpand
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