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Cochlear Inner Hair Cell Ribbon Synapse is the Primary Target of Ototoxic Aminoglycoside Stimuli
TLDR
It is reported that quantitative changes in the number of IHC ribbon synapses and hearing loss occur in response to gentamicin treatment in mice, and ribbon synaptic plasticity may require the quantitative changes to play self-protective role adapted to ototoxic aminoglycoside stimuli. Expand
Long noncoding RNA-LET, which is repressed by EZH2, inhibits cell proliferation and induces apoptosis of nasopharyngeal carcinoma cell
TLDR
It is found that lncRNA-LET was significantly downregulated in nasopharyngeal carcinoma (NPC) tissues compared with corresponding normal tissues and is transcriptional repressed by EZH2-mediated H3K27 histone methylation on the LET promoter, revealing an epigenetic mechanism for lnc RNA-LET dysregulation. Expand
EphA2/ephrinA1 mRNA expression and protein production in adenoid cystic carcinoma of salivary gland.
TLDR
The present study showed a high expression of EphA2/ephrinA1 in adenoid cystic carcinoma and can serve as a novel therapy target for adenoids cysts carcinoma. Expand
Prediction of Mild Cognitive Impairment Conversion Using a Combination of Independent Component Analysis and the Cox Model
TLDR
A combination of ICA and Cox model analyses could be used successfully in survival analysis and provide a network-based perspective of MCI progression or AD-related studies. Expand
MicroRNA-21 regulates the viability and apoptosis of diffuse large B-cell lymphoma cells by upregulating B cell lymphoma-2.
TLDR
Since miR-21 may contribute to increased viability and decreased apoptosis of DLBCL cells through targeting B cl-2, both Bcl-2 and mi R-21 are likely to serve as effective targets for developing novelDLBCL treatments in the future. Expand
Posterior decompression and short segmental pedicle screw fixation combined with vertebroplasty for Kümmell’s disease with neurological deficits
TLDR
Posterior decompression with short-segment fixation and fusion combined with vertebroplasty is an effective treatment for Kümmell’s disease with neurological deficits. Expand
Inner hair cell ribbon synapse plasticity might be molecular basis of temporary hearing threshold shifts in mice.
TLDR
It is reported that an acoustic stimulation induced TTS in mice, with the maximal ABR threshold elevations seen on the 4(th) day after noise exposure, which may indicate that noise exposure can cause a decline in cochlear ribbon synapses and result in consequent hearing loss. Expand
Myosin VIIa and otoferlin in cochlear inner hair cells have distinct response to ototoxic exposure
Abstract Conclusion: Ototoxic gentamicin exposure does not disrupt the expression of myosin VIIa in the inner hair cells (IHCs) of mice, whereas gentamicin ototoxicity causes altered expression ofExpand
Continuous adsorption of Pb(II) and methylene blue by engineered graphite oxide coated sand in fixed-bed column
Abstract The mixture of several effluents, caused by the improper handling and management of effluents, generated multi-component wastewater containing both metals and dyes, leading to theExpand
DNA origami-based shape IDs for single-molecule nanomechanical genotyping
TLDR
A set of differentially shaped, highly hybridizable self-assembled DNA origami nanostructures serving as shape IDs for magnified nanomechanical imaging of single-nucleotide polymorphisms is developed and expected to hold great potential in genetic analysis at the single-molecule level. Expand
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