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Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase
The Escherichia coli inducible lysine decarboxylase, LdcI/CadA, together with the inner‐membrane lysine‐cadaverine antiporter, CadB, provide cells with protection against mild acidic conditionsExpand
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Dynamics of the ClpP serine protease: A model for self-compartmentalized proteases
Abstract ClpP is a highly conserved serine protease present in most bacterial species and in the mitochondria of mammalian cells. It forms a cylindrical tetradecameric complex arranged into twoExpand
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Chaperones and Proteases of Plasmodium falciparum
In 2010, there were about 216 million malaria cases and an estimated 655,000 deaths (WHO). With half of the world’s population living in endemic regions, the struggle against this parasite is moreExpand
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Intravitreal triamcinolone staining observation of residual undetached cortical vitreous after posterior vitreous detachment
AimsTo study the pattern of residual undetached cortical vitreous (RCV) after posterior vitreous detachment (PVD) in eyes with rhegmatogenous retinal detachment (RRD) and to examine the relationshipExpand
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Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins
A 3.3 MDa macromolecular cage between two Escherichia coli proteins with seemingly incompatible symmetries–the hexameric AAA+ ATPase RavA and the decameric inducible lysine decarboxylase LdcI–isExpand
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Structural insights into the Escherichia coli lysine decarboxylases and molecular determinants of interaction with the AAA+ ATPase RavA
The inducible lysine decarboxylase LdcI is an important enterobacterial acid stress response enzyme whereas LdcC is its close paralogue thought to play mainly a metabolic role. A uniqueExpand
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Near-Infrared Spectroscopy Study of Language Activated Hyper- and Hypo-Oxygenation in Human Prefrontal Cortex
Oxygenation changes in the left prefrontal cortex during language processing were assessed with near-infrared spectroscopy (NIRS). Oxyhemoglobin and deoxyhemoglobin concentrations at the Fp1 siteExpand
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Mechanism of Amyloidogenesis of a Bacterial AAA+ Chaperone.
Amyloids are fibrillar protein superstructures that are commonly associated with diseases in humans and with physiological functions in various organisms. The precise mechanisms of amyloid formationExpand
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Investigation of the Mechanism and Structure of the Cage-like Complex formed by the Escherichia coli Inducible Lysine Decarboxylase LdcI and the MoxR AAA+ ATPase RavA
The gram-negative bacteria Escherichia coli, a neutralophile, is remarkable in its defenses against acid stress. Of interest to our laboratory is the inducible lysine decarboxylase (LdcI) system, anExpand