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The development of a critical appraisal tool for use in systematic reviews addressing questions of prevalence.
BACKGROUND Recently there has been a significant increase in the number of systematic reviews addressing questions of prevalence. Key features of a systematic review include the creation of an aExpand
Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data
Aim:There currently does not exist guidance for authors aiming to undertake systematic reviews of observational epidemiological studies, such as those reporting prevalence and incidence information.Expand
Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.
The hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha are closely related, key transcriptional regulators of the hypoxic response, countering a low oxygen situation with the up-regulation ofExpand
Turn me on: regulating HIF transcriptional activity
  • K. Lisy, D. Peet
  • Biology, Medicine
  • Cell Death and Differentiation
  • 1 April 2008
The hypoxia-inducible factors (HIFs) are critical for cellular adaptation to limiting oxygen and regulate a wide array of genes when cued by cellular oxygen-sensing mechanisms. HIF is able to directExpand
Enablers and barriers to the implementation of primary health care interventions for Indigenous people with chronic diseases: a systematic review
BackgroundAccess to appropriate, affordable, acceptable and comprehensive primary health care (PHC) is critical for improving the health of Indigenous populations. Whilst appropriate infrastructure,Expand
Conducting systematic reviews of association (etiology): The Joanna Briggs Institute's approach
ABSTRACTThe systematic review of evidence is the research method which underpins the traditional approach to evidence-based healthcare. There is currently no uniform methodology for conducting aExpand
Cell-specific Regulation of Hypoxia-inducible Factor (HIF)-1α and HIF-2α Stabilization and Transactivation in a Graded Oxygen Environment*
The hypoxia-inducible factor (HIF)-1α and HIF-2α are closely related, key transcriptional regulators of the hypoxic response, countering a low oxygen situation with the up-regulation of target genesExpand
Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis
This systematic review investigated whether the insulin sensitiser metformin has a geroprotective effect in humans. Pubmed and Embase were searched along with databases of unpublished studies.Expand
Effectiveness of mifamurtide in addition to standard chemotherapy for high-grade osteosarcoma: a systematic review
Background Osteosarcoma mostly occurs during the period of rapid bone growth in children and adolescents as high-grade osteosarcomas. Current treatment recommended for high-grade non-metastatic andExpand
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