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Current status of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis from colorectal cancer.
TLDR
It can be concluded that CRS and HIPEC offers a chance for long-term survival in selected patients with PC of colorectal origin, and the most relevant prognostic parameters are discussed.
[Diagnosis and treatment of colorectal liver metastases - workflow].
TLDR
Patients with colorectal liver metastases should be treated in centres with experience in liver surgery, and in situ ablative procedures (radiofrequency ablation = RFA and laser-induced interstitial thermotherapy = LITT) are local therapy options in selected patients who are not candidates for resection.
Differential expression of CD44 splice variants in human pancreatic adenocarcinoma and in normal pancreas.
TLDR
Immunohistochemical screening of pancreatic adenocarcinomas from 24 different patients and 9 pancreatic carcinoma cell lines revealed variant CD44 expression in all specimens tested, suggesting the presence alone but the chain composition of the CD44 variant chains could be important for their altered function.
Thymidylate synthase is a predictor for response and resistance in hepatic artery infusion chemotherapy.
TLDR
The results indicate that TS quantitation is a valuable predictive marker for tumor response to HAI therapy in patients with colorectal liver metastases.
Association of Plane of Total Mesorectal Excision With Prognosis of Rectal Cancer: Secondary Analysis of the CAO/ARO/AIO-04 Phase 3 Randomized Clinical Trial
TLDR
This phase 3 randomized clinical trial confirms the long-term clinical effect of TME plane quality on local recurrence, as initially reported in the MRC CR07 study and highlights the key role of pathologists and surgeons in the multidisciplinary management of rectal cancer.
In vitro concentration response studies and in vitro phase II tests as the experimental basis for regional chemotherapeutic protocols.
TLDR
From results and clinical considerations, optimal times were defined for the regional chemotherapy strategies of hepatic artery infusion, intraperitoneal instillation, and chemoembolisation as performed at the authors' institution.
Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial
TLDR
The risk of late disease relapse was significantly lower in patients with MSI-H compared with MSS colon cancer and B2M mutations should be evaluated as a potential prognostic marker in future clinical trials.
Are Colon and Rectal Cancer Two Different Tumor Entities? A Proposal to Abandon the Term Colorectal Cancer
TLDR
It is concluded that CC is not the same as RC, and the term “CRC” should no longer be used as a single entity in basic and clinical research as well as other areas of classification.
Adjuvant treatment of colon and rectal cancer: impact of chemotherapy, radiotherapy, and immunotherapy on routine postsurgical patient management. Forschungsgruppe Onkologie Gastrointestinaler
TLDR
Intraportal infusion may be as effective as systemic adjuvant treatment; the tumor type and stage for which benefit from this kind of treatment is consistently significant needs to be defined, since intraportsal infusion of all resectable colorectal cancers is overtreatment.
Palliative and adjuvant regional chemotherapy in pancreatic cancer.
TLDR
Hepatic disease progression appeared to be suppressed with CAI, which also appears to be effective for palliative and adjuvant treatment in non-resectable and resected pancreatic cancer.
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