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Zonation of hepatic cytochrome P-450 expression and regulation.
Recent studies on the expression and induction of CYP enzymes in the perivenous region probably have important toxicological implications, since many CYP-activated chemicals cause cell injury primarily in this region of the liver. Expand
Zonation of cytochrome P450 expression, drug metabolism and toxicity in liver.
  • K. Lindros
  • Biology, Medicine
  • General pharmacology
  • 1 February 1997
Because many hepatotoxins cause zone-specific damage, further unravelling the factors governing zonal expression of phase I and phase II enzymes will be necessary to clarify how drug-specific patterns of liver damage arise. Expand
Blood acetaldehyde concentration gradient between hepatic and antecubital venous blood in ethanol‐intoxicated alcoholics and controls*
In thirteen chronic lcoholics the elevation of blood acetaldehyde was more constant in the hepatic than in the peripheral vein, and in 13 chronic l alcoholics in spite of the absence of detectable levels in simultaneously taken antecubital blood. Expand
Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease
The results suggest that in the relatively isolated Finnish population, the T allele confers increased risk of alcoholic liver damage, and in particular, TT homozygotes are at a high risk to develop cirrhosis. Expand
Hepatic expression of multiple acute phase proteins and down-regulation of nuclear receptors after acute endotoxin exposure.
It is suggested that acute LPS treatment induces important early transcription factors and co-ordinately down-regulates nuclear receptors, and that this results in altered expression of a large number of downstream genes. Expand
Models of alcoholic liver disease in rodents: a critical evaluation.
This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan, where Christiane Bode, Alexandr Parlesak, and J. Christian Bode presented the course of the pathological spectrum of alcoholic liver disease in humans. Expand
Zonated expression of cytokines in rat liver: Effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole
The results show the zonated expression of several cytokines and the counteraction of CMZ on all effects of ethanol on cytokine expression, strengthening a link between increased CYP2E1 expression and enhanced cytokineexpression as important events in the development of ALD. Expand
Sex difference in alcohol-related organ injury.
This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan, where sex differences in ethanol pharmacokinetics and alcohol metabolism in Asian subjects were presented. Expand
Activation of complement components and reduced regulator expression in alcohol-induced liver injury in the rat.
Results suggest an induction of complement-activating capacity in the liver after chronic ethanol treatment and the reduced expression of the critical complement regulatory proteins Crry and CD59 may sensitize the liver to complement-mediated damage. Expand
Utilization and metabolic effects of acetaldehyde and ethanol in the perfused rat liver.
The results support the view that ultimately the rate of mitochondrial oxidation of NADH limits the removal of ethanol in the liver. Expand