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Microarray analysis of eosinophils reveals a number of candidate survival and apoptosis genes.
Microarray technologies were used to investigate the changes in the messenger RNA expression profile of eosinophils after treatment with interleukin (IL)-5, and identification of Pim-1 and SLP-76 as regulated by IL-5 led to suggest a direct role for these proteins in theIL-5 signaling pathway in eosInophils. Expand
Molecular Cloning, Functional Expression and Pharmacological Characterization of the Human Metabotropic Glutamate Receptor Type 2
Northern blot analyses showed that hmGluR2 is widely expressed in different regions of the adult brain as well as in fetal human brain, and reduced the depression of forskolin‐induced cAMP accumulation by (1S,3R)‐ACPD in both human and rat mGLUR2. Expand
Molecular phenotyping of HCS-2/8 cells as an in vitro model of human chondrocytes.
This study confirms how careful one needs to be in choosing in vitro model systems for investigating effects of interest and shows that HCS-2/8 cultured at confluence are most closely related to primary chondrocytes. Expand
Analysis of cellular adhesion by microarray expression profiling.
A microarray platform to identify genes in a number of different pathological conditions, particularly those with an inflammation component, is established, using the output of an eosinophil sequencing project in which 1069 sequences were identified that were not represented in the public domain. Expand