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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Reticulon 3 Binds the 2C Protein of Enterovirus 71 and Is Required for Viral Replication*
- Wen-Fang Tang, Shing-Ying Yang, +7 authors J. Horng
- Biology, Medicine
- Journal of Biological Chemistry
- 23 February 2007
Reduced production of reticulon 3 by RNA interference markedly reduced the synthesis of enterovirus 71-encoded viral proteins and replicative double-stranded RNA, reducing plaque formation and apoptosis, and reintroduction of nondegradable reticULon 3 into these knockdown cells rescued enterov virus 71 infectivity, and viral protein and double-Stranded RNA synthesis. Expand
Overexpression of CLIC1 in human gastric carcinoma and its clinicopathological significance
Experimental results indicate that overexpression of CLIC1 is a potential prognostic marker for gastric cancer. Expand
Expression of mutant thyroid hormone nuclear receptors in human hepatocellular carcinoma cells
The high prevalence of TR mutations found in the tumors of patients with hepatocellular carcinoma suggests that mutant TRs could play an important role in liver carcinogenesis. Expand
Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism
It is suggested that T3 regulates lipid metabolism through a C19orf80-activated autophagic process, as observed from lipidated LC3 (LC3-II) and levels of oxygen consumption rate, respectively. Expand
Repression of microRNA-130b by thyroid hormone enhances cell motility.
A novel pathway interlinking T3/TR, miR-130b, IRF1, the EMT-related genes, p-mTOR, p -STAT3 and the p-AKT cascade, which regulates the motility and invasion of hepatoma cells is highlighted. Expand
Valproic acid enhances Oct4 promoter activity in myogenic cells
- H. Teng, Y. Kuo, +6 authors Shen-Liang Chen
- Biology, Medicine
- Journal of cellular biochemistry
- 1 April 2010
Observations identify a molecular mechanism by which VPA directly regulate Oct4 expression to ensure the acquirement and maintenance of pluripotency. Expand
Taurine up‐regulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma
It is shown that knockdown of taurine up‐regulated gene 1 (TUG1) induces marked inhibition of cell migration, invasion, and glycolysis through suppression of microRNA (miR)‐455‐3p, and novel regulatory associations among TUG1, miR, AMPKβ2, and HK2 are an important determinant ofglycolytic metabolism and metastasis in HCC cells. Expand
MicroRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer.
Together, miR-196a/-196b inhibitory oligonucleotides or overexpression of the radixin may have therapeutic potential in suppressing GC metastasis. Expand
Intracellular distribution of the endogenous and transfected beta form of thyroid hormone nuclear receptor visualized by the use of domain-specific monoclonal antibodies.
To study the regulation, tissue distribution, and subcellular localization of nuclear receptor for thyroid hormone, monoclonal antibodies (mAbs) against the human placental c-erbA (hTR beta 1)… Expand