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Safety, tolerability and pharmacokinetics of udenafil, a novel PDE-5 inhibitor, in healthy young Korean subjects.
Udenafil was generally well tolerated in these healthy subjects, and no serious adverse events occurred, and the area under the time-concentration curves (AUC) and maximum plasma concentrations (C(max)) increased supraproportionally with increasing dose in the single-dose study.
Evaluation of Endogenous Metabolic Markers of Hepatic CYP3A Activity Using Metabolic Profiling and Midazolam Clearance
It is demonstrated that a combination of the concentrations and ratios of several endogenous metabolites and the CYP3A5*3 genotype is a reliable predictive marker of hepatic CYP 3A activity as assessed by i.v. administration of midazolam.
Pharmacokinetic and Pharmacodynamic Interaction of Lorazepam and Valproic Acid in Relation to UGT2B7 Genetic Polymorphism in Healthy Subjects
It is suggested that the UGT2B7 genotype probably affects lorazepam–valproate pharmacodynamic interaction, especially in subjects who have homovariant genotypes of UGT3B7 and UGT1B15, although the effects on the pharmacokinetics are less significant.
Multiple-dose pharmacokinetics and pharmacodynamics of evogliptin (DA-1229), a novel dipeptidyl peptidase IV inhibitor, in healthy volunteers
Repeated administration of evogliptin in healthy subjects was well tolerated and exhibited linear pharmacokinetic and pharmacodynamic profiles and tolerability within the 5–20 mg dose range.
Aspirin Decreases Systemic Exposure to Clopidogrel Through Modulation of P‐Glycoprotein But Does Not Alter Its Antithrombotic Activity
  • J. Oh, D. Shin, I. Jang
  • Biology, Chemistry
    Clinical pharmacology and therapeutics
  • 1 June 2014
Findings indicate low‐dose aspirin coadministration may decrease clopidogrel bioavailability but does not decrease its efficacy.
Effects of Proton Pump Inhibitors on Metformin Pharmacokinetics and Pharmacodynamics
Concomitant administration of PPIs with metformin significantly increased plasma met formin exposure, but the effects on glucose disposition were minor and varied depending on the PPI administered.