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Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo.
It is shown that acute myeloid leukemia (AML) cells from most patients with AML are deficient in a critical enzyme required for arginine synthesis, argininosuccinate synthetase-1 (ASS1), thus, these ASS1-deficient AML cells are dependent on importing extracellularArginine.
Syndrome of Inappropriate Secretion of Antidiuretic Hormone Associated with Imatinib
Monitoring for SIADH is recommended if a patient receiving high-dose imatinib develops hyponatremia, which is the first reported case of imatinIB-inducedSIADH.
Determination of benzoylurea insecticide residues in tomatoes by high-performance liquid chromatography with ultraviolet-diode array and atmospheric pressure chemical ionization-mass spectrometry
The results indicate that the developed LC/MS method is accurate, precise, and sensitive for quantitative and qualitative analysis at low levels of benzoylureas required by legislation.
Validation of Two Variations of the QuEChERS Method for the Determination of Multiclass Pesticide Residues in Cereal-Based Infant Foods by LC–MS/MS
Over the past years to ensure food safety and particular for food that intend to be consumed by infants and young children, the European Union has adopted specific legislation concerning the control
The microenvironment of AIDS-related diffuse large B-cell lymphoma provides insight into the pathophysiology and indicates possible therapeutic strategies.
The analysis showed that AR-DLBCL is highly angiogenic with higher blood-vessel density than sporadic cases and highlighted the role of Epstein-Barr virus in angiogenesis and the reactive cytotoxic cell infiltrates.