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Biomedical applications of polymer-composite materials: a review
An overview of various biomedical applications of polymer-composite materials reported in the literature over the last 30 years is presented in this paper. For the benefit of the readers, generalExpand
Scaffolding in tissue engineering: general approaches and tissue-specific considerations
The functions of scaffolds and the major scaffolding approaches as important guidelines for selecting scaffolds are reviewed and the tissue-specific considerations for scaffolding are discussed, using intervertebral disc as an example. Expand
Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency.
  • H. Mao, K. Roy, +5 authors K. Leong
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 23 February 2001
The chitosan-DNA nanoparticles could partially protect the encapsulated plasmid DNA from nuclease degradation as shown by electrophoretic mobility analysis and three different schemes to conjugate transferrin or KNOB protein to the nanoparticle surface were developed. Expand
Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage.
The significance of nanotopography in directing differentiation of adult stem cells is demonstrated with significant up-regulation of neuronal markers such as microtubule-associated protein 2 (MAP2) compared to unpatterned and micropatterned controls. Expand
Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
It is demonstrated that oral allergen-gene immunization with chitosan–DNA nanoparticles is effective in modulating murine anaphylactic responses, and its prophylactic utility in treating food allergy is indicated. Expand
Sustained release of proteins from electrospun biodegradable fibers.
This study investigated the feasibility of encapsulating human beta-nerve growth factor (NGF), which was stabilized in a carrier protein, bovine serum albumin (BSA) in a copolymer of epsilon-caprolactone and ethyl ethylene phosphate (PCLEEP) by electrospinning to produce biofunctional tissue scaffolds. Expand
Aligned Protein-Polymer Composite Fibers Enhance Nerve Regeneration: A Potential Tissue-Engineering Platform.
It is demonstrated that, without further modification, plain electrospun fibers can help in peripheral nerve regeneration; however, the synergistic effect of an encapsulated growth factor facilitated a more significant recovery. Expand
Advanced materials and processing for drug delivery: the past and the future.
In this review, this review focuses on the materials innovation and processing of drug delivery systems and how these advances have shaped the past and may influence the future of drug Delivery. Expand
Electrohydrodynamics: A facile technique to fabricate drug delivery systems.
The state-of-the-art of using electrohydrodynamic technique to generate nanofiber/particles as drug delivery devices to enhance the material's functionality in tissue engineering applications is discussed. Expand
DNA-polycation nanospheres as non-viral gene delivery vehicles.
Although the transfection efficiency of the nanospheres was typically lower than that of lipofectamine and calcium phosphate controls in cell culture, the beta-gal expression in muscle of BALB/c mice was higher and more sustained than that achieved by naked DNA and lip ofectamine complexes. Expand