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Increased site-specific phosphorylation of tyrosine hydroxylase accompanies stimulation of enzymatic activity induced by cessation of dopamine neuronal activity.
Activation of striatal dopamine (DA) neurons by neuroleptic treatment or by electrical stimulation of the nigrostriatal pathway increases the activity of tyrosine hydroxylase (TH). The increase isExpand
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Role of Serine‐19 Phosphorylation in Regulating Tyrosine Hydroxylase Studied with Site‐ and Phosphospecific Antibodies and Site‐Directed Mutagenesis
Abstract: The effects of depolarization by elevated potassium concentrations were studied in PC12 cells and in stably transfected AtT‐20 cells expressing wild‐type or [Leu19]‐recombinant tyrosineExpand
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Enhanced Anti‐tumour Effects of Acriflavine in Combination with Guanosine in Mice
  • S. Kim, C. W. Kim, +4 authors Y. Han
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1 February 1997
The anti‐tumour activity of acriflavine in combination with guanosine has been evaluated in solid or ascitic tumour‐implanted animal models. Guanosine is known to potentiate the anti‐tumour effectsExpand
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Inhibition of the biologic effects of endotoxin on neutrophils by polymyxin B sulfate.
Polymyxin B sulfate diminished the endotoxin-mediated release of human blood neutrophil lysosomal enzymes. Similarly, this antibiotic reduced the endotoxin-induced increase in the neutrophil hexoseExpand
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Interaction of aflatoxins B1 and G1 with tissues of the rat.
Summary The incorporation of tritium-labeled aflatoxins B 1 and G 1 into DNA, RNA, and soluble protein of liver, kidney, spleen, and intestine of rats has been examined. The variation of the amountExpand
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Morphological characteristics of dopaminergic immunoreactive neurons in the olfactory bulb of the common marmoset monkey (Callithrix jacchus).
The present study describes the distribution of tyrosine hydroxylase (TH)-immunoreactive (IR) elements in the olfactory bulb of the common marmoset monkey (Callithrix jacchus), a primate species byExpand
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Enhancement of human neutrophil bactericidal activity by chemotactic factors.
Neutrophils are important effector cells in the defense against microorganisms. They migrate into infected sites and then phagocytose and kill bacteria. Chemotactic factors may be important forExpand
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Regulation of tyrosine hydroxylase phosphorylation in PC12 pheochromocytoma cells by elevated K+ and nerve growth factor. Evidence for different mechanisms of action.
A specific antiserum was used to compare phosphorylation of tyrosine hydroxylase (TH) (EC 1.14.16.2, tyrosine 3-monooxygenase) as regulated by elevated K+ and nerve growth factor (NGF) in culturedExpand
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