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Recent advances in the investigation of curcuminoids
More than 30 Curcuma species (Zingiberaceae) are found in Asia, where the rhizomes of these plants are used as both food and medicine, such as in traditional Chinese medicine. The plants are usuallyExpand
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Little or no ability of obestatin to interact with ghrelin or modify motility in the rat gastrointestinal tract
Obestatin, encoded by the ghrelin gene may inhibit gastrointestinal (GI) motility. This activity was re‐investigated.
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Identification of MEK1 as a novel target for the treatment of neuropathic pain
In the present study we have attempted to identify changes in gene expression which are associated with neuropathic pain using subtractive suppression hybridization analysis of the lumbar spinal cordExpand
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Perspectives on Biologically Active Camptothecin Derivatives
Camptothecins (CPTs) are cytotoxic natural alkaloids that specifically target DNA topoisomerase I. Research on CPTs has undergone a significant evolution from the initial discovery of CPT in the lateExpand
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Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents.
Little information has been reported on the antitumor effects of the diterpenoid alkaloid constituents of Aconitum plants, used in the herbal drug 'bushi'. This study was aimed at determining theExpand
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Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine
This article will review selected herbal products used in traditional Chinese medicine, including medicinal mushrooms (巴西蘑菇 bā xī mó gū; Agaricus blazei, 雲芝 yún zhī; Coriolus versicolor, 靈芝 líng zhī;Expand
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Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.
  • K. Lee
  • Biology, Medicine
  • Journal of natural products
  • 26 March 2010
Medicinal plants have long been an excellent source of pharmaceutical agents. Accordingly, the long-term objectives of the author's research program are to discover and design new chemotherapeuticExpand
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Current developments in the discovery and design of new drug candidates from plant natural product leads.
  • K. Lee
  • Biology, Medicine
  • Journal of natural products
  • 1 February 2004
This review article will emphasize recent research in the Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, on various classes of plant-derived compoundsExpand
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Identification and synthesis of quinolizidines with anti-influenza a virus activity.
Influenza A virus infection causes a contagious respiratory illness that poses a threat to human health. However, there are limited anti-influenza A therapeutics available, which is furtherExpand
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Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library.
The HIV-1 capsid (CA) protein plays essential roles in both early and late stages of HIV-1 replication and is considered an important, clinically unexploited therapeutic target. As such, smallExpand
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