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Real-Time Monitoring of ATP-Responsive Drug Release Using Mesoporous-Silica-Coated Multicolor Upconversion Nanoparticles.
Stimuli-responsive drug delivery vehicles have garnered immense interest in recent years due to unparalleled progress made in material science and nanomedicine. However, the development ofExpand
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Single vehicular delivery of siRNA and small molecules to control stem cell differentiation.
Achieving a controlled and reproducible means to direct stem cell differentiation is the single most critical concern scientists have been trying to address since the discovery of stem cells. In thisExpand
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Design, synthesis, and characterization of graphene-nanoparticle hybrid materials for bioapplications.
Graphene is composed of single-atom thick sheets of sp2 bonded carbon atoms that are arranged in a perfect two-dimensional (2D) honeycomb lattice. Because of this structure, graphene is characterizedExpand
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SERS-Based Quantification of Biomarker Expression at the Single Cell Level Enabled by Gold Nanostars and Truncated Aptamers.
Surface-enhanced Raman spectroscopy (SERS)-based biosensors have been used increasingly over the past few years for cancer detection and diagnosis. SERS-based imaging offers excellent sensitivity andExpand
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NanoScript: A Nanoparticle-Based Artificial Transcription Factor for Effective Gene Regulation
Transcription factor (TF) proteins are master regulators of transcriptional activity and gene expression. TF-based gene regulation is a promising approach for many biological applications; however,Expand
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Incorporation of functionalized gold nanoparticles into nanofibers for enhanced attachment and differentiation of mammalian cells
BackgroundElectrospun nanofibers have been widely used as substrata for mammalian cell culture owing to their structural similarity to natural extracellular matrices. Structurally consistentExpand
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Selective isolation and noninvasive analysis of circulating cancer stem cells through Raman imaging.
Circulating cancer stem cells (CCSCs), a rare circulating tumor cell (CTC) type, recently arose as a useful resource for monitoring and characterizing both cancers and their metastatic derivatives.Expand
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Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway
Summary Cyclophilin A (CypA) is over-expressed in a number of human cancer types, but the mechanisms by which CypA promotes oncogenic properties of cells are not understood. Here we demonstrate thatExpand
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Photo-triggerable Hydrogel-Nanoparticle Hybrid Scaffolds for Remotely Controlled Drug Delivery.
Remotely-triggerable drug delivery systems enable the user to adjust dosing regimens on-demand based on a patient's physiological response and clinical needs. However, currently reported systems areExpand
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Magnetic Oleosome as a Functional Lipophilic Drug Carrier for Cancer Therapy.
In the present study, we fabricated magnetic oleosomes functionalized with recombinant proteins as a new carrier for oil-based lipophilic drugs for cancer treatment. The bioengineered oleosome isExpand
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