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Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.
Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins.Expand
Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice.
Treatment with E-harpagoside or MCA-Hg to scopolamine-induced amnesic mice significantly decreased TBARS level which was accompanied by an increase in the activities or contents of glutathione reductase, SOD and reduced GSH. Expand
ESP-102, a standardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, significantly improved scopolamine-induced memory impairment in mice.
The results suggest that ESP-102 may have some protective characteristics against neuronal cell death and cognitive impairments often observed in Alzheimer's disease, stroke, ischemic injury and other neurodegenerative diseases. Expand
Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines.
The results suggest that these flavonoids possess therapeutic potentials as a multipotent agent against neurodegenerative diseases related to oxidative stress and pathological inflammatory responses. Expand
Protective effects of standardized Thuja orientalis leaves against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.
  • M. Ju, Pyeongjae Lee, +5 authors M. Oh
  • Biology, Medicine
  • Toxicology in vitro : an international journal…
  • 1 April 2010
Although the etiology of Parkinson's disease (PD) remains unknown, recent studies have suggested that oxidative stress (OS) and apoptosis, as a result of mitochondrial defects, may play importantExpand
Optimization of pressurized liquid extraction for spicatoside A in Liriope platyphylla
Abstract Method development based on pressurized liquid extraction technique was investigated for the extraction of spicatoside A from Liriope platyphylla. Determination of spicatoside A was carriedExpand
Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities.
  • N. Cho, K. Lee, +5 authors S. Sung
  • Chemistry, Medicine
  • Food and chemical toxicology : an international…
  • 1 August 2013
Conclusively, it is demonstrated that R. vernciflua bark extract and its active flavonoids with potent neuroprotective and anti-inflammatory effects might be good therapeutic candidates as cognitive-enhancers. Expand
The effects of lignan-riched extract of Shisandra chinensis on amyloid-β-induced cognitive impairment and neurotoxicity in the cortex and hippocampus of mouse.
Oral treatment of ESP-806 significantly attenuated Aβ1-42-induced memory impairment evaluated by behavioral tests and suggested that the extract of Schisandra chinensis fruits riched with dibenzocyclooctadiene lignans may be useful in the prevention and treatment of Alzheimer's disease. Expand
Anti-amnestic activity of E-p-methoxycinnamic acid from Scrophularia buergeriana.
  • S. Kim, S. Kang, +4 authors Y. Kim
  • Psychology, Medicine
  • Brain research. Cognitive brain research
  • 15 July 2003
The anti-amnestic activities of phenylpropanoids in mice with amnesia induced in vivo by scopolamine are examined and E-p-MCA may ultimately hold significant therapeutic value in alleviating certain memory impairments observed in dementia. Expand
Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice
Oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory and indicated that logan in may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition. Expand