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CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content
TLDR
Entry and exit of proteins into flagella is gauged by CEP290 in the transition zone by measuring the concentration of Na6(CO3)2, Na2SO4, and Na2CO3 in the fluid mechanics of the response to EMT.
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The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella
The Bardet-Biedl syndrome protein complex (BBSome) is a cargo adapter rather than an essential part of the intraflagellar transport (IFT) machinery.
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IFT-Cargo Interactions and Protein Transport in Cilia.
  • K. Lechtreck
  • Biology
    Trends in biochemical sciences
  • 1 December 2015
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A Differential Cargo-Loading Model of Ciliary Length Regulation by IFT
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Mutations in Hydin impair ciliary motility in mice
TLDR
It is concluded that hydrocephalus in hydin mutants is caused by a central pair defect impairing ciliary motility and fluid transport in the brain.
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Centrin deficiency in Chlamydomonas causes defects in basal body replication, segregation and maturation
TLDR
It is proposed that basal body segregation in Chlamydomonas depends on an extranuclear array of microtubules independent of the mitotic spindle, and centrin deficiency interferes with basal body development.
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Tubulin transport by IFT is upregulated during ciliary growth by a cilium-autonomous mechanism
In Chlamydomonas cilia, IFT concentrates soluble tubulin by regulating IFT train occupancy and thereby promotes elongation of axonemal microtubules.
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Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity.
TLDR
The results suggest a challenging possibility, namely, that centrosome activity could depend upon nucleocytoplasmic exchange of centrosomal proteins and local Ran-dependent concentration at the Centrosome.
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Chlamydomonas reinhardtii hydin is a central pair protein required for flagellar motility
TLDR
Biochemical analyses revealed that hydin interacts with the CP proteins CPC1 and kinesin-like protein 1 (KLP1) and probably involved in the CP–radial spoke control pathway that regulates dynein arm activity.
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HA-tagging of putative flagellar proteins in Chlamydomonas reinhardtii identifies a novel protein of intraflagellar transport complex B.
TLDR
Genes encoding IFT25 homologues are absent from the genomes of organisms that lack cilia and flagella and, interestingly, also from those of Drosophila melanogaster and Caenorhabditis elegans, suggesting that IFT 25 has a specialized role in IFT that is not required for the assembly of cilia or flagellum in the worm and fly.
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