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Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology.
In biological fluids, proteins bind to the surface of nanoparticles to form a coating known as the protein corona, which can critically affect the interaction of the nanoparticles with living… Expand
Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers.
The current gold standard to reduce non-specific cellular uptake of drug delivery vehicles is by covalent attachment of poly(ethylene glycol) (PEG). It is thought that PEG can reduce protein… Expand
Differential uptake of functionalized polystyrene nanoparticles by human macrophages and a monocytic cell line.
Tumor cell lines are often used as models for the study of nanoparticle-cell interactions. Here we demonstrate that carboxy (PS-COOH) and amino functionalized (PS-NH2) polystyrene nanoparticles of… Expand
Miniemulsion polymerization and the structure of polymer and hybrid nanoparticles.
- K. Landfester
- Materials Science, Medicine
- Angewandte Chemie
- 8 June 2009
The miniemulsion process allows the formation of complex structured polymeric nanoparticles and the encapsulation of a solid or liquid, an inorganic or organic, or a hydrophobic or hydrophilic… Expand
The effect of carboxydextran-coated superparamagnetic iron oxide nanoparticles on c-Jun N-terminal kinase-mediated apoptosis in human macrophages.
Superparamagnetic iron oxide nanoparticles are frequently used for cell labeling or as diagnostic contrast media, yet studies analyzing their effects on immune cells remain scarce. Here we… Expand
Uptake mechanism of oppositely charged fluorescent nanoparticles in HeLa cells.
- J. Dausend, A. Musyanovych, +4 authors V. Mailaender
- Chemistry, Medicine
- Macromolecular bioscience
- 8 December 2008
The endocytotic mechanisms involved in the uptake of charged polystyrene nanoparticles into HeLa cells were investigated. Uptake experiments were done in the presence or absence of drugs known to… Expand
Amino-functionalized polystyrene nanoparticles activate the NLRP3 inflammasome in human macrophages.
Specifically designed and functionalized nanoparticles hold great promise for biomedical applications. Yet, the applicability of nanoparticles is critically predetermined by their surface… Expand
Polyreactions in miniemulsions.
- K. Landfester
- Materials Science
- 1 August 2001
The process of miniemulsification allows the generation of small, homogeneous, and stable droplets of monomer or polymer precursors, which are then transformed by (as many as possible) polymer… Expand
Protein corona of nanoparticles: distinct proteins regulate the cellular uptake.
Understanding nanoparticle-protein interactions is a crucial issue in the development of targeted nanomaterial delivery. Besides unraveling the composition of the nanoparticle's protein coronas,… Expand
Uptake of functionalized, fluorescent-labeled polymeric particles in different cell lines and stem cells.
Labeling of cells with particles for in-vivo detection is interesting for various biomedical applications. The objective of this study was to evaluate the feasibility and efficiency labeling of cells… Expand