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Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia.
OBJECTIVE In the present study, we sought to develop/characterize the pain profile of a rat model of surgically induced osteoarthritis (OA). METHODS OA was surgically induced in male Lewis ratsExpand
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Streptococcal cell wall-induced arthritis: requirements for IL-4, IL-10, IFN-gamma, and monocyte chemoattractant protein-1.
Intra-articular injection of streptococcal cell wall Ag followed by i.v. challenge ("reactivation") results in a destructive lymphocyte-dependent monoarticular arthritis. To further define the roleExpand
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Characterization of the airway smooth muscle muscarinic receptor in vivo.
We examined the bronchodilator activity of eight subtype-selective and non-selective muscarinic antagonists in anesthetized, ventilated guinea pigs bronchoconstricted by carbachol aerosols. RelativeExpand
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Effects of the phosphodiesterase inhibitor rolipram on streptococcal cell wall-induced arthritis in rats.
The phosphodiesterase-IV (PDE-IV) inhibitor, rolipram, is antiinflammatory in a number of animal models and inhibits the release of a variety of cytokines, including TNFalpha. Arthritis induced inExpand
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NPC 15669 inhibits the reversed passive Arthus reaction in rats by blocking neutrophil recruitment.
NPC 15669, N-carboxy-L-leucine,N-[(2,7-dimethylfluoren-9-yl)methyl]ester, has been shown to inhibit several inflammatory reactions that depend upon recruitment of neutrophils into the primary lesion.Expand
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Pulmonary pharmacology of a novel, smooth muscle-selective muscarinic antagonist in vivo.
The need for a smooth muscle-selective muscarinic antagonist that could provide oral bronchodilator activity with minimal side effects has led to the discovery ofExpand
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Airway smooth muscle selectivity of the muscarinic antagonist DAC 5945 in vivo.
We investigated the M3/M2 antagonist selectivity of [N-iminomethyl-N'-[(2-hydroxy-2-phenyl-2-cyclohexyl)-ethyl] piperazine HCI (DAC 5945) in vivo. ED50 values for reversal of methacholine-inducedExpand
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Methoctramine induces nonspecific airway hyperresponsiveness in vivo.
We investigated the effects of subtype-selective muscarinic receptor antagonists upon aerosol antigen-induced bronchoconstriction in anesthetized guinea pigs. Neither pirenzepine (muscarinic M1Expand
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