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Rat model of arterial thrombosis induced by ferric chloride.
FeCl3 dose-dependently induced formation of an occlusive mixed thrombus that was indexed by monitoring the time between FeCl3 application and a rapid temperature decrease in the carotid artery of the rat. Expand
Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats.
Blood pressure reduction more closely paralleled the in vitro and in vivo potency of these agents toward vascular alpha rather than 5HT2 receptors. Expand
LY53857, a selective and potent serotonergic (5-HT2) receptor antagonist, does not lower blood pressure in the spontaneously hypertensive rat.
The lack of effectiveness of LY53857 to lower blood pressure in the SHR indicates that blockade of both central and vascular serotonin receptors is not a sufficient mechanism to lowerBlood pressure in this model of hypertension. Expand
Mechanisms of enhanced renin secretion during CO2 retention in dogs.
Engineering the proteolytic specificity of activated protein C improves its pharmacological properties
The ability to selectively modulate substrate specificity and subsequently affect in vivo performance is demonstrated and therapeutic opportunities for the use of protein C derivatives in disease states with elevated serine protease inhibitor levels are suggested. Expand
Preclinical studies on LY237733, a potent and selective serotonergic antagonist.
The in vitro radioligand displacement studies showed that LY237733 has a preferential affinity for 5-HT1c and5-HT2 receptors compared to other monoaminergic receptors, which has provided the pre-clinical rationale to evaluate the effects of this compound in the treatment of sexual disorders such as psychogenic erectile dysfunction, and other therapeutic indications for a 5- HT2 antagonist, including depression, anxiety, schizophrenia and migraine. Expand
Pressor Responses to Norepinephrine in Rabbits with 3‐Day and 30‐Day Renal Artery Stenosis: The Role of Angiotensin II
It is shown that the increased pressor response to norepinephrine infusions in rabbits with renal artery stenosis occurs before the onset of hypertension and thus is not merely a result of the hypertension. Expand
Effect of acute oral administration of captopril and MK-421 on vascular angiotensin converting enzyme activity in the spontaneously hypertensive rat.
Abstract Vascular angiotensin converting enzyme (ACE) may be important as a potential site of action for the antihypertensive effect of ACE inhibitors. ACE activity, estimated by hydrolysis of [ 3 H]Expand